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Title

Acute and repeated dose (4 weeks) oral toxicity studies of two antihypertensive peptides, RYLGY and AYFYPEL, that correspond to fragments (90–94) and (143–149) from αs1-casein

AuthorsAnadón, A.; Ares, I.; Ramos, E.; Martínez-Larrañaga, M. R.; Contreras, María del Mar CSIC ORCID; Ramos González, María Mercedes CSIC ; Recio, Isidra CSIC ORCID
KeywordsCasein hydrolysate
RYLGY and AYFYPEL antihypertensive peptides
Safety evaluation
Issue DateJul-2010
PublisherElsevier
Pergamon Press
CitationFood and Chemical Toxicology 48(7): 1836-1845 (2010)
AbstractThe Lowpept® is a powdered casein hydrolysate containing the antihypertensive peptides RYLGY and AYFYPEL, two sequences that correspond to αs1-casein f (90–94) (RYLGY)1 and αs1-casein f (143–149) (AYFYPEL)1. To support the safety, Lowpept® has been examined in an acute and in a 4-week repeated dose oral toxicity studies in rats. Powdered casein hydrolysate administered in a single oral gavage dose of 2000 mg/kg resulted in no adverse events or mortality. Also, casein hydrolysate administered as a daily dose of 1000 mg/kg for 4 weeks by gavage resulted in no adverse events or mortality. No evidence or treatment-related toxicity was detected during both studies. Data analysis of body weight gain, food consumption, clinical observations, blood biochemical, haematology, organ weight ratios and histopathological findings did not show significant differences between control and treated groups. It is concluded that the casein hydrolysate containing the peptides RYLGY and AYFYPEL orally administered to rats was safe and that not treatment-related toxicity was detected even at the highest doses investigated in both acute (2000 mg/kg of body weight) and repeated dose (4 weeks) oral (1000 mg/kg of body weight) toxicity studies.
Publisher version (URL)https://doi.org/10.1016/j.fct.2010.04.016
URIhttp://hdl.handle.net/10261/256336
DOI10.1016/j.fct.2010.04.016
ISSN0278-6915
Appears in Collections:(IFI) Artículos




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