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Título

Drug absorption through a cell monolayer: A theoretical work on a non-linear three-compartment model

AutorKomin, Niko ; Toral, Raúl
Palabras claveAbsorption kinetics
Efflux mechanisms
Fecha de publicación1-ene-2009
EditorElsevier
CitaciónEuropean Journal of Pharmaceutical Sciences 37: 106-114 (2009)
ResumenThe subject of analysis is a non-linear three-compartment model, widely used in pharmacological absorption studies. It has been transformed into a general form, thus leading automatically to an appropriate approximation. This made the absorption profile accessible and expressions for absorption times, apparent permeabilities and equilibrium values were given. These findings allowed a profound analysis of results from non-linear curve fits and delivered the dependencies on the systems parameters over a wide range of values. The results were applied to an absorption experiment with multidrug transporter-affected antibiotic CNV97100 on Caco-2 cell monolayers.
DescripciónArXiv pre-print: http://arxiv.org/abs/0805.3757
Versión del editorhttp://dx.doi.org/10.1016/j.ejps.2009.01.005
URIhttp://hdl.handle.net/10261/25502
DOI10.1016/j.ejps.2009.01.005
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