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Título: | Drug absorption through a cell monolayer: A theoretical work on a non-linear three-compartment model |
Autor: | Komin, Niko CSIC; Toral, Raúl CSIC ORCID | Palabras clave: | Absorption kinetics Efflux mechanisms |
Fecha de publicación: | 1-ene-2009 | Editor: | Elsevier | Citación: | European Journal of Pharmaceutical Sciences 37: 106-114 (2009) | Resumen: | The subject of analysis is a non-linear three-compartment model, widely used in pharmacological absorption studies. It has been transformed into a general form, thus leading automatically to an appropriate approximation. This made the absorption profile accessible and expressions for absorption times, apparent permeabilities and equilibrium values were given. These findings allowed a profound analysis of results from non-linear curve fits and delivered the dependencies on the systems parameters over a wide range of values. The results were applied to an absorption experiment with multidrug transporter-affected antibiotic CNV97100 on Caco-2 cell monolayers. | Descripción: | ArXiv pre-print: http://arxiv.org/abs/0805.3757 | Versión del editor: | http://dx.doi.org/10.1016/j.ejps.2009.01.005 | URI: | http://hdl.handle.net/10261/25502 | DOI: | 10.1016/j.ejps.2009.01.005 |
Aparece en las colecciones: | (IFISC) Artículos |
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0805.3757v4.pdf | 581,7 kB | Adobe PDF | Visualizar/Abrir |
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