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Título

Nanotechnology-based strategies to overcome current barriers in gene delivery

AutorMirón-Barroso, Sofía CSIC ORCID; Domènech, Elena B.; Trigueros, Sonia CSIC ORCID
Palabras claveNanotechnology
Nanomaterials
Nanomedicine
Delivery
Gene therapy
Genetic material
Gene therapeutics
Biological barriers
Cancer
Fecha de publicación2021
EditorMultidisciplinary Digital Publishing Institute
CitaciónInternational Journal of Molecular Science 22(16): 8537 (2021)
ResumenNanomaterials are currently being developed for the specific cell/tissue/organ delivery of genetic material. Nanomaterials are considered as non-viral vectors for gene therapy use. However, there are several requirements for developing a device small enough to become an efficient genedelivery tool. Considering that the non-viral vectors tested so far show very low efficiency of gene delivery, there is a need to develop nanotechnology-based strategies to overcome current barriers in gene delivery. Selected nanostructures can incorporate several genetic materials, such as plasmid DNA, mRNA, and siRNA. In the field of nanotechnologies, there are still some limitations yet to be resolved for their use as gene delivery systems, such as potential toxicity and low transfection efficiency. Undeniably, novel properties at the nanoscale are essential to overcome these limitations. In this paper, we will explore the latest advances in nanotechnology in the gene delivery field.
Descripción© 2021 by the authors.
Versión del editorhttps://doi.org/10.3390/ijms22168537
URIhttp://hdl.handle.net/10261/254705
DOI10.3390/ijms22168537
ISSN1661-6596
E-ISSN1422-0067
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