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Título: | Nanotechnology-based strategies to overcome current barriers in gene delivery |
Autor: | Mirón-Barroso, Sofía CSIC ORCID; Domènech, Elena B.; Trigueros, Sonia CSIC ORCID | Palabras clave: | Nanotechnology Nanomaterials Nanomedicine Delivery Gene therapy Genetic material Gene therapeutics Biological barriers Cancer |
Fecha de publicación: | 2021 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | International Journal of Molecular Science 22(16): 8537 (2021) | Resumen: | Nanomaterials are currently being developed for the specific cell/tissue/organ delivery of genetic material. Nanomaterials are considered as non-viral vectors for gene therapy use. However, there are several requirements for developing a device small enough to become an efficient genedelivery tool. Considering that the non-viral vectors tested so far show very low efficiency of gene delivery, there is a need to develop nanotechnology-based strategies to overcome current barriers in gene delivery. Selected nanostructures can incorporate several genetic materials, such as plasmid DNA, mRNA, and siRNA. In the field of nanotechnologies, there are still some limitations yet to be resolved for their use as gene delivery systems, such as potential toxicity and low transfection efficiency. Undeniably, novel properties at the nanoscale are essential to overcome these limitations. In this paper, we will explore the latest advances in nanotechnology in the gene delivery field. | Descripción: | © 2021 by the authors. | Versión del editor: | https://doi.org/10.3390/ijms22168537 | URI: | http://hdl.handle.net/10261/254705 | DOI: | 10.3390/ijms22168537 | ISSN: | 1661-6596 | E-ISSN: | 1422-0067 |
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Nanotechnology_Miron_PV_Art2021.pdf | 1,43 MB | Adobe PDF | Visualizar/Abrir |
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