Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/254692
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dc.contributor.authorGonzález-Bosch, Carmenes_ES
dc.contributor.authorBoorman, E.es_ES
dc.contributor.authorZunszain, P.A.es_ES
dc.contributor.authorMann, G.E.es_ES
dc.date.accessioned2021-11-29T06:26:52Z-
dc.date.available2021-11-29T06:26:52Z-
dc.date.issued2021-10-14-
dc.identifier.citationRedox Biology 47: 102165 (2021)es_ES
dc.identifier.issn2213-2317-
dc.identifier.urihttp://hdl.handle.net/10261/254692-
dc.description.abstractShort-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet, have been linked to beneficial effects on human health associated with their metabolic and signaling properties. Their physiological functions are related to their aliphatic tail length and dependent on the activation of specific membrane receptors. In this review, we focus on the mechanisms underlying SCFAs mediated protection against oxidative and mitochondrial stress and their role in regulating metabolic pathways in specific tissues. We critically evaluate the evidence for their cytoprotective roles in suppressing inflammation and carcinogenesis and the consequences of aging. The ability of these natural compounds to induce signaling pathways, involving nuclear erythroid 2-related factor 2 (Nrf2), contributes to the maintenance of redox homeostasis under physiological conditions. SCFAs may thus serve as nutritional and therapeutic agents in healthy aging and in vascular and other diseases such as diabetes, neuropathologies and cancer.es_ES
dc.description.sponsorshipThe authors acknowledge the support of Heart Research UK (Ref. RG2672, G.E.M.), British Heart Foundation (FS/15/6/31298, G.E.M.), Evgen Pharma (G.E.M.), Medical Research Council (E.B., P.Z., G.E.M.), Spanish Ministry of Science, Innovation and Universities (PRX19/00247, C.G.B.)es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationMICIU/ICTI2017-2020/PRX19-00247es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectShort-chain fatty acidses_ES
dc.subjectMedium-chain fatty acides_ES
dc.subjectLong-chain fatty acidses_ES
dc.subjectRedox signalinges_ES
dc.subjectKeap1-Nrf2es_ES
dc.subjectEpigeneticses_ES
dc.subjectInflammationes_ES
dc.subjectCardiovascular diseaseses_ES
dc.subjectNeurodegenerative diseaseses_ES
dc.subjectCanceres_ES
dc.subjectAginges_ES
dc.titleShort-chain fatty acids as modulators of redox signaling in health and diseasees_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.redox.2021.102165-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.redox.2021.102165es_ES
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.contributor.funderBritish Heart Foundationes_ES
dc.contributor.funderEvgen Pharmaes_ES
dc.contributor.funderMedical Research Council (UK)es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairetypeartículo-
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