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Título: | The SV40 T antigen modulates CBP histone acetyltransferase activity |
Autor: | Aragón Valls, Esther; Cruz, Xavier de la CSIC ORCID; Martínez-Balbás, Marian CSIC ORCID | Fecha de publicación: | 15-jun-2003 | Editor: | Oxford University Press | Citación: | Nucleic Acids Research 31(12): 3114–3122 (2003) | Resumen: | Histone acetyltransferases (HATs) play a key role in transcription control, cell proliferation and differentiation by modulating chromatin structure; however, little is known about their own regulation. Here we show that expression of the viral oncoprotein SV40 T antigen increases histone acetylation and global cellular HAT activities. In addition, it enhances CREB-binding protein HAT activity and modulates its transcriptional activity. Finally, we show that inhibition of cellular histone deacetylases by trichostatin A increases the SV40 infectivity rate. These findings highlight the importance of histone acetylation in the regulation of the cell cycle by oncoviral proteins. | Descripción: | 9 pages, 6 figures, 1 table.-- PMID: 12799439 [PubMed].-- PMCID: PMC162251. | Versión del editor: | http://dx.doi.org/10.1093/nar/gkg418 | URI: | http://hdl.handle.net/10261/25391 | DOI: | 10.1093/nar/gkg418 | ISSN: | 0305-1048 | E-ISSN: | 1362-4962 |
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