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dc.contributor.authorGómez-Moutón, Concepción-
dc.contributor.authorAbad, José Luis-
dc.contributor.authorMira, Emilia-
dc.contributor.authorLacalle, Rosa Ana-
dc.contributor.authorGallardo, Eduard-
dc.contributor.authorJiménez Baranda, Sonia-
dc.contributor.authorIlla, Isabel-
dc.contributor.authorBernad, Antonio-
dc.contributor.authorMañes, Santos-
dc.contributor.authorMartínez, Carlos-
dc.date.accessioned2010-06-15T12:18:58Z-
dc.date.available2010-06-15T12:18:58Z-
dc.date.issued2001-08-14-
dc.identifier.citationProceedings of the National Academy of Sciences of the USA 98(17): 9642-9647 (2001)en_US
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10261/25297-
dc.description6 pages, 7 figures.-- PMID: 11493690 [PubMed].-- PMCID: PMC55505.-- Available online Aug 7, 2001.en_US
dc.description.abstractRedistribution of specialized molecules in migrating cells develops asymmetry between two opposite cell poles, the leading edge and the uropod. We show that acquisition of a motile phenotype in T lymphocytes results in the asymmetric redistribution of ganglioside GM3- and GM1-enriched raft domains to the leading edge and to the uropod, respectively. This segregation to each cell pole parallels the specific redistribution of membrane proteins associated to each raft subfraction. Our data suggest that raft partitioning is a major determinant for protein redistribution in polarized T cells, as ectopic expression of raft-associated proteins results in their asymmetric redistribution, whereas non-raft-partitioned mutants of these proteins are distributed homogeneously in the polarized cell membrane. Both acquisition of a migratory phenotype and SDF-1α-induced chemotaxis are cholesterol depletion-sensitive. Finally, GM3 and GM1 raft redistribution requires an intact actin cytoskeleton, but is insensitive to microtubule disruption. We propose that membrane protein segregation not only between raft and nonraft domains but also between distinct raft subdomains may be an organizational principle that mediates redistribution of specialized molecules needed for T cell migration.en_US
dc.description.sponsorshipThis work was supported by grants from the Spanish Secretaría de Estado de Política Científica y Tecnológica/European Union, the Comunidad Autónoma de Madrid, and the Pharmacia Corporation. The Department of Immunology and Oncology was founded and is supported by the Spanish National Research Council and the Pharmacia Corporation.en_US
dc.format.extent1250110 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherNational Academy of Sciences (U.S.)en_US
dc.rightsopenAccessen_US
dc.subjectCell structureen_US
dc.subjectT cell polarizationen_US
dc.subjectLipidsen_US
dc.subjectLeading-Edge Proteinsen_US
dc.titleSegregation of leading-edge and uropod components into specific lipid rafts during T cell polarizationen_US
dc.typeartículoen_US
dc.identifier.doi10.1073/pnas.171160298-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1073/pnas.171160298en_US
dc.identifier.e-issn1091-6490-
dc.identifier.pmid11493690-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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