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Título: | A two-hybrid screening of human Tau protein: interactions with Alu-derived domain |
Autor: | Hoenicka, Janet; Arrasate, Montserrat; García de Yébenes, Justo; Ávila, Jesús CSIC ORCID | Fecha de publicación: | 2002 | Editor: | Lippincott Williams & Wilkins | Citación: | Neuroreport 13(3): 343-349 (2002) | Resumen: | The microtubule associated protein tau has been implicated in several neurodegenerative diseases, grouped as tauopathies. To search for tau-associated proteins, the two-hybrid system was used with tau as a bait and an adult human brain cDNA library as a source of putative interacting proteins. We have identified two positive clones consisting of an Alu-derived amino acid sequence that binds to tau and show moderate homology with a motif found in several neuronal proteins related to neurodegenerative disorders. We have also demonstrated that the Alu-derived motif interacts in vitro with tau and may be involved in modulation of its phosphorylation. These findings suggest the existence of tau-binding proteins that are able to bind to tau through their Alu-derived sequence in a direct way. The possible interaction of these proteins with tau could play a role in its cellular localization, regulate the amount of phosphorylated tau and also be involved in the pathological processes of tauopathies. | Versión del editor: | https://doi.org/10.1097/00001756-200203040-00019 | URI: | http://hdl.handle.net/10261/252203 | DOI: | 10.1097/00001756-200203040-00019 | ISSN: | 0959-4965 |
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