Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/252016
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Phosphorylation of stathmin modulates its function as a microtubule depolymerizing factor |
Autor: | Moreno, Francisco J.; Ávila, Jesús CSIC ORCID | Fecha de publicación: | 1998 | Editor: | Springer Nature | Citación: | Molecular and Cellular Biochemistry 183: 201–210 (1998) | Resumen: | Oncoprotein 18 or stathmin was isolated from bovine brain, characterized and novel features of its function as a microtubule depolymerizing factor were tested. The effect of phosphorylation of stathmin on its function as a microtubule depolymerizing factor has been tested in vitro. Five different protein kinases, protein kinase A, MAP kinase, cdc2 kinase, glycogen synthase kinase 3 and casein kinase 2, were used to modify stathmin, since it is known that these kinases could phosphorylate several residues that are modified in vivo and could have important roles in stathmin function. The residues phosphorylated in vitro by the different protein kinases were identified and in some cases they correspond to those modified in vivo. Recombinant unphosphorylated stathmin and native stathmin, which was previously dephosphorylated with alkaline phosphatase, showed similar microtubule depolymerizing activity. This activity is higher than that of stathmin phosphorylated by protein kinase A, MAP kinase or cdc 2 kinase, whereas phosphorylation of the protein with casein kinase 2 or glycogen synthase kinase 3 resulted in a slight increase of the depolymerizing activity. | Versión del editor: | https://doi.org/10.1023/A:1006807814580 | URI: | http://hdl.handle.net/10261/252016 | DOI: | 10.1023/A:1006807814580 | ISSN: | 0300-8177 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 59,24 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
25
checked on 25-abr-2024
WEB OF SCIENCETM
Citations
26
checked on 16-feb-2024
Page view(s)
40
checked on 22-abr-2024
Download(s)
7
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.