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Título

The therapeutic potential of novel isobenzofuranones against Naegleria fowleri

AutorRizo-Liendo, Aitor; Arberas-Jiménez, Íñigo; Sifaoui, Ines; Gkolfi, Dimitra; Santana, Yiset; Cotos, Leandro CSIC; Tejedor, David CSIC ORCID CVN ; García-Tellado, Fernando CSIC ORCID ; Piñero, José E.; Lorenzo-Morales, Jacob
Palabras claveNaegleria
Therapeutics
Isobenzofuranones
Programmed cell death
Encephalitis
Fecha de publicacióndic-2021
EditorElsevier
CitaciónInternational Journal for Parasitology: Drugs and Drug Resistance 17: 139-149 (2021)
ResumenThe Free-Living Amoeba species, Naegleria fowleri is the causative agent of a lethal encephalitis known as Primary Amoebic Encephalitis (PAM). Moreover, most of the reported cases are often related to swimming and/or diving in aquatic environments. In addition, the current therapeutic options against PAM are not fully effective and hence, there is an urgent need to develop novel therapeutic agents against this disease. Previously isobenzofuranones compounds have been reported to present antiprotozoal and antifungal activity among others. However, to the best of our knowledge, these molecules have not been previously tested against N. fowleri. Therefore, the aim of this study was to evaluate the activity of 14 novel isobenzofuranones against this pathogenic amoeba. The most active and less toxic molecules, were assayed in order to check induction of Programmed Cell Death (PCD) in the treated amoebae. The obtained results showed that these molecules were able to eliminate N. fowleri trophozoites and also induced PCD. Therefore, the tested isobenzofuranones could be potential therapeutic candidates for the treatment of PAM.
Versión del editorhttps://doi.org/10.1016/j.ijpddr.2021.09.004
URIhttp://hdl.handle.net/10261/251840
DOI10.1016/j.ijpddr.2021.09.004
E-ISSN2211-3207
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