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dc.contributor.author | Pollier, Jacob | es_ES |
dc.contributor.author | Moses, Tessa | es_ES |
dc.contributor.author | González-Guzmán, Miguel | es_ES |
dc.contributor.author | De Geyter, Nathan | es_ES |
dc.contributor.author | Lippens, Saskia | es_ES |
dc.contributor.author | Vanden Bossche, Robin | es_ES |
dc.contributor.author | Marhavý, Peter | es_ES |
dc.contributor.author | Kremer, Anna | es_ES |
dc.contributor.author | Morreel, Kris | es_ES |
dc.contributor.author | Guérin, Christopher J. | es_ES |
dc.contributor.author | Tava, Aldo | es_ES |
dc.contributor.author | Oleszek, Wieslaw | es_ES |
dc.contributor.author | Thevelein, Johan M. | es_ES |
dc.contributor.author | Campos, Narciso | es_ES |
dc.contributor.author | Goormachtig, Sofie | es_ES |
dc.contributor.author | Goossens, Alain | es_ES |
dc.date.accessioned | 2021-09-20T06:51:33Z | - |
dc.date.available | 2021-09-20T06:51:33Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Nature 504: 148–152 (2013) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/250507 | - |
dc.description.abstract | Jasmonates are ubiquitous oxylipin-derived phytohormones that are essential in the regulation of many development, growth and defence processes. Across the plant kingdom, jasmonates act as elicitors of the production of bioactive secondary metabolites that serve in defence against attackers. Knowledge of the conserved jasmonate perception and early signalling machineries is increasing, but the downstream mechanisms that regulate defence metabolism remain largely unknown. Here we show that, in the legume Medicago truncatula, jasmonate recruits the endoplasmic-reticulum-associated degradation (ERAD) quality control system to manage the production of triterpene saponins, widespread bioactive compounds that share a biogenic origin with sterols. An ERAD-type RING membrane-anchor E3 ubiquitin ligase is co-expressed with saponin synthesis enzymes to control the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the rate-limiting enzyme in the supply of the ubiquitous terpene precursor isopentenyl diphosphate. Thus, unrestrained bioactive saponin accumulation is prevented and plant development and integrity secured. This control apparatus is equivalent to the ERAD system that regulates sterol synthesis in yeasts and mammals but that uses distinct E3 ubiquitin ligases, of the HMGR degradation 1 (HRD1) type, to direct destruction of HMGR. Hence, the general principles for the management of sterol and triterpene saponin biosynthesis are conserved across eukaryotes but can be controlled by divergent regulatory cues. | es_ES |
dc.description.sponsorship | This research has received funding from the Agency for Innovation by Science and Technology in Flanders (‘Strategisch Basisonderzoek’ Combiplan project SBO040093), the European Union Seventh Framework Programme FP7/2007-2013 under grant agreement number 222716 –SMARTCELL and the Spanish Ministerio de Economía y Competitividad under grant BFU2011-24208. T.M. and N.D.G. are indebted to the VIB International PhD Fellowship Program and the Agency for Innovation by Science and Technology for predoctoral fellowships, respectively. J.P. and S.L. are postdoctoral fellows of the Research Foundation Flanders (FWO). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/222716 | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | es_ES |
dc.title | The protein quality control system manages plant defence compound synthesis | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1038/nature12685 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/nature12685 | es_ES |
dc.identifier.e-issn | 1476-4687 | - |
dc.contributor.funder | Research Foundation - Flanders | es_ES |
dc.contributor.funder | Institute for the Promotion of Innovation by Science and Technology in Flanders | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003130 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (CRAG) Artículos (IBMCP) Artículos |
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