Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/250507
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

The protein quality control system manages plant defence compound synthesis

AuthorsPollier, Jacob; Moses, Tessa; González-Guzmán, Miguel; De Geyter, Nathan; Lippens, Saskia; Vanden Bossche, Robin; Marhavý, Peter; Kremer, Anna; Morreel, Kris; Guérin, Christopher J.; Tava, Aldo; Oleszek, Wieslaw; Thevelein, Johan M.; Campos, Narciso CSIC ORCID; Goormachtig, Sofie; Goossens, Alain
Issue Date2013
PublisherNature Publishing Group
Springer Nature
CitationNature 504: 148–152 (2013)
AbstractJasmonates are ubiquitous oxylipin-derived phytohormones that are essential in the regulation of many development, growth and defence processes. Across the plant kingdom, jasmonates act as elicitors of the production of bioactive secondary metabolites that serve in defence against attackers. Knowledge of the conserved jasmonate perception and early signalling machineries is increasing, but the downstream mechanisms that regulate defence metabolism remain largely unknown. Here we show that, in the legume Medicago truncatula, jasmonate recruits the endoplasmic-reticulum-associated degradation (ERAD) quality control system to manage the production of triterpene saponins, widespread bioactive compounds that share a biogenic origin with sterols. An ERAD-type RING membrane-anchor E3 ubiquitin ligase is co-expressed with saponin synthesis enzymes to control the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the rate-limiting enzyme in the supply of the ubiquitous terpene precursor isopentenyl diphosphate. Thus, unrestrained bioactive saponin accumulation is prevented and plant development and integrity secured. This control apparatus is equivalent to the ERAD system that regulates sterol synthesis in yeasts and mammals but that uses distinct E3 ubiquitin ligases, of the HMGR degradation 1 (HRD1) type, to direct destruction of HMGR. Hence, the general principles for the management of sterol and triterpene saponin biosynthesis are conserved across eukaryotes but can be controlled by divergent regulatory cues.
Publisher version (URL)https://doi.org/10.1038/nature12685
URIhttp://hdl.handle.net/10261/250507
DOI10.1038/nature12685
E-ISSN1476-4687
Appears in Collections:(CRAG) Artículos
(IBMCP) Artículos

Files in This Item:
File Description SizeFormat
theprotesynthe.pdf743,14 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

SCOPUSTM   
Citations

87
checked on Jan 19, 2022

WEB OF SCIENCETM
Citations

79
checked on Jan 14, 2022

Page view(s)

37
checked on Jan 19, 2022

Download(s)

37
checked on Jan 19, 2022

Google ScholarTM

Check

Altmetric

Dimensions


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.