English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/25042
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 36 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury

AutorCortés-Canteli, Marta ; Luna Medina, Rosario de ; Sanz-SanCristóbal, Marina ; Álvarez Barrientos, Alberto; Santos, Ángel; Pérez Castillo, Ana
Palabras claveC/EBPβ
Excitotoxicity
Inflammation
Neurodegeneration
Fecha de publicación15-abr-2008
EditorCompany of Biologists
CitaciónJournal of Cell Science 121(8): 1224-1234 (2008)
ResumenThe CCAAT/enhancer-binding protein beta (C/EBPbeta, also known as CEBPB) was first identified as a regulator of differentiation and inflammatory processes in adipose tissue and liver. Although C/EBPbeta was initially implicated in synaptic plasticity, its function in the brain remains largely unknown. We have previously shown that C/EBPbeta regulates the expression of genes involved in inflammatory processes and brain injury. Here, we have demonstrated that the expression of C/EBPbeta is notably increased in the hippocampus in a murine model of excitotoxicity. Mice lacking C/EBPbeta showed a reduced inflammatory response after kainic acid injection, and exhibited a dramatic reduction in pyramidal cell loss in the CA1 and CA3 subfields of the hippocampus. These data reveal an essential function for C/EBPbeta in the pathways leading to excitotoxicity-mediated damage and suggest that inhibitors of this transcription factor should be evaluated as possible neuroprotective therapeutic agents.
Descripción11 pages, 7 figures.-- Supplementary material available online at http://jcs.biologists.org/cgi/content/full/121/8/1224/DC1
Versión del editorhttp://dx.doi.org/10.1242/jcs.025031
URIhttp://hdl.handle.net/10261/25042
DOI10.1242/jcs.025031
ISSN0021-9533
Aparece en las colecciones: (IIBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
CCAAT Enhancer Binding.pdf8,38 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.