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Título: | Complete Analysis of the Epidemiological Scenario around a SARS-CoV-2 Reinfection: Previous Infection Events and Subsequent Transmission |
Autor: | Pérez Lago, Laura; Pérez Latorre, Leire; Herranz, Marta; Tejerina, Francisco; Sola-Campoy, Pedro J.; Sicilia, Jon; Suárez-González, Julia; Andrés-Zayas, Cristina; Chiner-Oms, Álvaro CSIC ORCID ; Jiménez-Serrano, Santiago CSIC ORCID; García-González, Neris; Comas, Iñaki CSIC ORCID ; González-Candelas, Fernando CSIC ORCID; Martínez-Laperche, Carolina; Catalán, Pilar; Muñoz, Patricia; García de Viedma, Darío CSIC ORCID; Gregorio Marañón Microbiology-ID COVID 19 Study Group | Palabras clave: | COVID-19 SARS-CoV-2 Genomics Reinfection Transmission |
Fecha de publicación: | 8-sep-2021 | Editor: | American Society for Microbiology | Citación: | mSphere 6(5):e0059621 | Resumen: | The first descriptions of reinfection by SARS-CoV-2 have been recently reported. However, these studies focus exclusively on the reinfected case, without considering the epidemiological context of the event. Our objectives were to perform a complete analysis of the sequential infections and community transmission events around a SARS-CoV-2 reinfection, including the infection events preceding it, the exposure, and subsequent transmissions. Our analysis was supported by host genetics, viral whole-genome sequencing, phylogenomic viral population analysis, and refined epidemiological data obtained from interviews with the involved subjects. The reinfection involved a 53-year-old woman with asthma (Case A), with a first COVID-19 episode in April 2020 and a much more severe second episode 4-1/2 months later, with SARS-CoV-2 seroconversion in August, that required hospital admission. An extended genomic analysis allowed us to demonstrate that the strain involved in Case A's reinfection was circulating in the epidemiological context of Case A and was also transmitted subsequently from Case A to her family context. The reinfection was also supported by a phylogenetic analysis, including 348 strains from Madrid, which revealed that the strain involved in the reinfection was circulating by the time Case A suffered the second episode, August-September 2020, but absent at the time range corresponding to Case A's first episode. IMPORTANCE We present the first complete analysis of the epidemiological scenario around a reinfection by SARS-CoV-2, more severe than the first episode, including three cases preceding the reinfection, the reinfected case per se, and the subsequent transmission to another seven cases. | Descripción: | 9 páginas, 3 figuras. The data that support the findings of this study (Fastq files) are publicly available. Fastq files above the GISAID thresholds were deposited at GISAID (hCoV-19/Spain/MD-IBV-99007733/2020, hCoV-19/Spain/MD-IBV-99007151/2020, hCoV-19/Spain/MD-IBV-99007734/2020, and hCoV-19/Spain/MDIBV-99007170/2020). All sequences were also deposited at the ENA (European Nucleotide Archive; https:// www.ebi.ac.uk/ena/browser/home) (ERR5698024, ERR5697187, ERR6459974, ERR5698025, and ERR5697254). | Versión del editor: | https://dx.doi.org/10.1128/mSphere.00596-21 | URI: | http://hdl.handle.net/10261/250220 | DOI: | 10.1128/mSphere.00596-21 | E-ISSN: | 2379-5042 |
Aparece en las colecciones: | (IBV) Artículos (I2SysBio) Artículos (PTI Salud Global) Colección Especial COVID-19 |
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Fichero | Descripción | Tamaño | Formato | |
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2021 mSphere 6-e0059621.pdf | 1,26 MB | Adobe PDF | Visualizar/Abrir |
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