Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/250220
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Complete Analysis of the Epidemiological Scenario around a SARS-CoV-2 Reinfection: Previous Infection Events and Subsequent Transmission

AutorPérez Lago, Laura; Pérez Latorre, Leire; Herranz, Marta; Tejerina, Francisco; Sola-Campoy, Pedro J.; Sicilia, Jon; Suárez-González, Julia; Andrés-Zayas, Cristina; Chiner-Oms, Álvaro CSIC ORCID ; Jiménez-Serrano, Santiago CSIC ORCID; García-González, Neris; Comas, Iñaki CSIC ORCID ; González-Candelas, Fernando CSIC ORCID; Martínez-Laperche, Carolina; Catalán, Pilar; Muñoz, Patricia; García de Viedma, Darío CSIC ORCID; Gregorio Marañón Microbiology-ID COVID 19 Study Group
Palabras claveCOVID-19
SARS-CoV-2
Genomics
Reinfection
Transmission
Fecha de publicación8-sep-2021
EditorAmerican Society for Microbiology
CitaciónmSphere 6(5):e0059621
ResumenThe first descriptions of reinfection by SARS-CoV-2 have been recently reported. However, these studies focus exclusively on the reinfected case, without considering the epidemiological context of the event. Our objectives were to perform a complete analysis of the sequential infections and community transmission events around a SARS-CoV-2 reinfection, including the infection events preceding it, the exposure, and subsequent transmissions. Our analysis was supported by host genetics, viral whole-genome sequencing, phylogenomic viral population analysis, and refined epidemiological data obtained from interviews with the involved subjects. The reinfection involved a 53-year-old woman with asthma (Case A), with a first COVID-19 episode in April 2020 and a much more severe second episode 4-1/2 months later, with SARS-CoV-2 seroconversion in August, that required hospital admission. An extended genomic analysis allowed us to demonstrate that the strain involved in Case A's reinfection was circulating in the epidemiological context of Case A and was also transmitted subsequently from Case A to her family context. The reinfection was also supported by a phylogenetic analysis, including 348 strains from Madrid, which revealed that the strain involved in the reinfection was circulating by the time Case A suffered the second episode, August-September 2020, but absent at the time range corresponding to Case A's first episode. IMPORTANCE We present the first complete analysis of the epidemiological scenario around a reinfection by SARS-CoV-2, more severe than the first episode, including three cases preceding the reinfection, the reinfected case per se, and the subsequent transmission to another seven cases.
Descripción9 páginas, 3 figuras. The data that support the findings of this study (Fastq files) are publicly available. Fastq files above the GISAID thresholds were deposited at GISAID (hCoV-19/Spain/MD-IBV-99007733/2020, hCoV-19/Spain/MD-IBV-99007151/2020, hCoV-19/Spain/MD-IBV-99007734/2020, and hCoV-19/Spain/MDIBV-99007170/2020). All sequences were also deposited at the ENA (European Nucleotide Archive; https:// www.ebi.ac.uk/ena/browser/home) (ERR5698024, ERR5697187, ERR6459974, ERR5698025, and ERR5697254).
Versión del editorhttps://dx.doi.org/10.1128/mSphere.00596-21
URIhttp://hdl.handle.net/10261/250220
DOI10.1128/mSphere.00596-21
E-ISSN2379-5042
Aparece en las colecciones: (IBV) Artículos
(I2SysBio) Artículos
(PTI Salud Global) Colección Especial COVID-19




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
2021 mSphere 6-e0059621.pdf1,26 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

PubMed Central
Citations

4
checked on 18-mar-2024

SCOPUSTM   
Citations

2
checked on 12-mar-2024

WEB OF SCIENCETM
Citations

2
checked on 25-feb-2024

Page view(s)

120
checked on 19-mar-2024

Download(s)

96
checked on 19-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


Artículos relacionados:


Este item está licenciado bajo una Licencia Creative Commons Creative Commons