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dc.contributor.authorSalvany, Lara-
dc.contributor.authorAldaz, Silvia-
dc.contributor.authorCorsetti, Elise-
dc.contributor.authorAzpiazu, Natalia-
dc.date.accessioned2010-06-02T18:24:28Z-
dc.date.available2010-06-02T18:24:28Z-
dc.date.issued2009-09-01-
dc.identifier.citationCell Cycle 8(17): 2748-55 (2009)en_US
dc.identifier.issn1538-4101-
dc.identifier.urihttp://hdl.handle.net/10261/24980-
dc.description.abstractIn drosophila, the preblastodermic syncytial nuclear divisions occur very fast. In this short period of time chromosomes must condense, segregate and decondense, in conditions governed by maternally provided RNAs and proteins. In this report, we show that the Homothorax (Hth) transcription factor is maternally provided and that its function is necessary for the proper assembly of the centric/centromeric heterochromatin during preblastodermic divisions. Embryos lacking the hth maternally-derived transcript, show abnormal localisation of the centromeric CID protein, and aberrant chromosomal segregation. In this syncytial context, Hth presumably acts together with its partner Extradenticle (Exd) and the RNA PolII, to facilitate transcription of satellite repeats. The transcripts derived from these sequences are needed for the correct assembly of the centric heterochromatin.en_US
dc.description.sponsorshipThe work was supported by grants CCG07-CSIC/SAL-1710 and BFU2008- 00815/BMC.en_US
dc.format.extent22195 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherLandes Bioscienceen_US
dc.rightsopenAccessen_US
dc.subjecttranscription factoren_US
dc.subjectheterochromatinen_US
dc.subjectsatellite DNAen_US
dc.subjectCentromeresen_US
dc.subjectsyncytiumen_US
dc.titleA new role for hth in the early pre-blastodermic divisions in drosophila.en_US
dc.typeartículoen_US
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://www.landesbioscience.com/journals/cc/article/9388/en_US
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
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