Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/24980
Share/Export:
logo share SHARE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

A new role for hth in the early pre-blastodermic divisions in drosophila.

AuthorsSalvany, Lara; Aldaz, Silvia CSIC; Corsetti, Elise; Azpiazu, Natalia CSIC
Keywordstranscription factor
heterochromatin
satellite DNA
Centromeres
syncytium
Issue Date1-Sep-2009
PublisherLandes Bioscience
CitationCell Cycle 8(17): 2748-55 (2009)
AbstractIn drosophila, the preblastodermic syncytial nuclear divisions occur very fast. In this short period of time chromosomes must condense, segregate and decondense, in conditions governed by maternally provided RNAs and proteins. In this report, we show that the Homothorax (Hth) transcription factor is maternally provided and that its function is necessary for the proper assembly of the centric/centromeric heterochromatin during preblastodermic divisions. Embryos lacking the hth maternally-derived transcript, show abnormal localisation of the centromeric CID protein, and aberrant chromosomal segregation. In this syncytial context, Hth presumably acts together with its partner Extradenticle (Exd) and the RNA PolII, to facilitate transcription of satellite repeats. The transcripts derived from these sequences are needed for the correct assembly of the centric heterochromatin.
Publisher version (URL)http://www.landesbioscience.com/journals/cc/article/9388/
URIhttp://hdl.handle.net/10261/24980
ISSN1538-4101
Appears in Collections:(CBM) Artículos




Files in This Item:
File Description SizeFormat
SalvanyCC8-17.pdf1,37 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

Page view(s)

310
checked on Jul 3, 2022

Download(s)

186
checked on Jul 3, 2022

Google ScholarTM

Check


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.