Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/24932
Share/Export:
![]() ![]() |
|
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Title: | A role for stroma-derived annexin A1 as mediator in the control of genetic susceptibility to T-cell lymphoblastic malignancies through prostaglandin E2 secretion |
Authors: | Santos, Javier CSIC ORCID; González-Sánchez, Laura CSIC ORCID; Matabuena-deYzaguirre, María; Villa-Morales, María CSIC ORCID; Cozar, Patricia; López-Nieva, Pilar CSIC ORCID; Fernández-Navarro, Pablo; Díaz-Muñoz, Manuel D.; Guenet, Jean-Louis; Montagutelli, Xavier; Fernández-Piqueras, José CSIC ORCID | Keywords: | Thymic-lymphomas gamma-irradiation low-penetrance-genes thymus-stroma Annexin A1 |
Issue Date: | 15-Mar-2009 | Publisher: | American Association for Cancer Research | Citation: | Cancer Research 69(6):2577-87(2009) | Abstract: | Cancer susceptibility is essentially attributable to multiple low-penetrance genes. Using interspecific consomic and congenic mice between the tumour-resistant SEG/Pas and the tumour-sensitive C57BL/6J strains, a region on chromosome 19 involved in the genetic resistance to γ-irradiation-induced T-cell lymphomas (Tlyr1) has been identified. Through the development of non-overlapping sub-congenic strains, it has been further demonstrated that Anxa1 may be a candidate resistance gene on the basis of its differential expression in thymus stroma cells after γ-radiation exposure. In addition, thymus-stroma cells of thymic lymphomas exhibited a significant reduction in the expression levels of Anxa1. Interestingly, the activity of Anxa1 relies on prostaglandin E2 (PGE2) induction that brings about apoptosis in thymocytes. In fact, in vitro transfection experiments revealed that PGE2 production was enhanced when HEK 293 cells were transfected with full-length cDNAs of Anxa1, with PGE2 production in the cells transfected with the allele of the resistant strain (Anxa1Tyr) being higher than that in cells transfected with the allele of the susceptible strain (Anxa1Phe). Furthermore, the presence of this compound in the medium induced apoptosis of immature CD4+CD8+CD3low cells in a dose-dependent manner. These results improve our knowledge of the molecular mechanisms triggering T-cell lymphoblastic lymphoma development, while highlighting the relevance of the stroma in controlling genetic susceptibility, and the use of PGE2 as a new therapeutic approach in T-cell haematogical malignancies. | Publisher version (URL): | http://dx.doi.org/10.1158/0008-5472.CAN-08-1821 | URI: | http://hdl.handle.net/10261/24932 | DOI: | 10.1158/0008-5472.CAN-08-1821 | ISSN: | 0008-5472 |
Appears in Collections: | (CBM) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FdezPiqueras_Cancer Research.pdf | 5,01 MB | Adobe PDF | ![]() View/Open |
Review this work
SCOPUSTM
Citations
9
checked on May 12, 2022
WEB OF SCIENCETM
Citations
8
checked on May 11, 2022
Page view(s)
429
checked on May 17, 2022
Download(s)
232
checked on May 17, 2022
Google ScholarTM
Check
Altmetric
Dimensions
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.