Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/249292
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Mathematical modelling of the diurnal regulation of the MEP pathway in Arabidopsis |
Autor: | Pokhilko, Alexandra; Bou Torrent, Jordi CSIC ORCID; Pulido, Pablo CSIC ORCID; Rodriguez-Concepcion, Manuel CSIC ORCID ; Ebenhöh, Oliver | Fecha de publicación: | 2015 | Editor: | Wiley-VCH | Citación: | New Phytologist 206(3): 1075-1085 (2015) | Resumen: | Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols, prenylated quinones and hormones are synthesised in chloroplasts via the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway. Here we develop a mathematical model of diurnal regulation of the MEP pathway in Arabidopsis thaliana. We used both experimental and theoretical approaches to integrate mechanisms potentially involved in the diurnal control of the pathway. Our data show that flux through the MEP pathway is accelerated in light due to the photosynthesis-dependent supply of metabolic substrates of the pathway and the transcriptional regulation of key biosynthetic genes by the circadian clock. We also demonstrate that feedback regulation of both the activity and the abundance of the first enzyme of the MEP pathway (1-deoxy-d-xylulose 5-phosphate synthase, DXS) by pathway products stabilizes the flux against changes in substrate supply and adjusts the flux according to product demand under normal growth conditions. These data illustrate the central relevance of photosynthesis, the circadian clock and feedback control of DXS for the diurnal regulation of the MEP pathway. | Versión del editor: | https://doi.org/10.1111/nph.13258 | URI: | http://hdl.handle.net/10261/249292 | DOI: | 10.1111/nph.13258 | E-ISSN: | 1469-8137 |
Aparece en las colecciones: | (CRAG) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 59,24 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
66
checked on 10-abr-2024
WEB OF SCIENCETM
Citations
57
checked on 21-feb-2024
Page view(s)
62
checked on 22-abr-2024
Download(s)
9
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.