Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/24916
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dc.contributor.authorRivas, Marcos-
dc.contributor.authorMellström, Britt-
dc.contributor.authorTorres, Begoña-
dc.contributor.authorCali, Gaetano-
dc.contributor.authorFerrara, Alfonso M.-
dc.contributor.authorTerracciano, Daniela-
dc.contributor.authorZannini, Mariastella-
dc.contributor.authorMorreale de Escobar, Gabriella-
dc.contributor.authorNaranjo, José Ramón-
dc.date.accessioned2010-06-01T12:00:28Z-
dc.date.available2010-06-01T12:00:28Z-
dc.date.issued2009-06-
dc.identifier.citationMolecular Endocrinology 23(6): 862-870 (2009)en_US
dc.identifier.issn0888-8809-
dc.identifier.urihttp://hdl.handle.net/10261/24916-
dc.description10 pages, 9 figures.en_US
dc.description.abstractG protein-coupled receptors (GPCRs) are involved in the pathophysiology of a wide range of diseases and constitute an attractive therapeutic target. In the thyroid gland, TSH receptor (TSHR), a member of the GPCR family, is a major regulator of thyroid differentiation and function. Alterations in TSHR activity are often involved in the development of pathologies such as thyroid cancer and thyroid enlargement (goiter). Here we show that DREAM (downstream regulatory element antagonist modulator) modulates TSHR activity through a direct protein-protein interaction that promotes coupling between the receptor and G{alpha}s. In transgenic mice, DREAM overexpression provokes a marked enlargement of the thyroid gland. Increased levels of DREAM protein were observed in human multinodular goiters, suggesting a novel etiopathogenic mechanism in nodular development in humans. Taken together, these findings identify a mechanism for the control of TSHR activity and provide a new approach for the study and treatment of thyroid pathologies associated with impaired TSHR function.en_US
dc.description.sponsorshipThis work was supported by grants from Ministerio de Ciencia e Innovación and Communidad Autonoma de Madrid (to J.R.N. and B.M.) and from Fondo de Investigaciones de la Seguridad (to M.R. and B.M.)en_US
dc.format.extent1706676 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherEndocrine Societyen_US
dc.rightsopenAccessen_US
dc.titleThe DREAM Protein Is Associated with Thyroid Enlargement and Nodular Developmenten_US
dc.typeartículoen_US
dc.identifier.doi10.1210/me.2008-0466-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1210/me.2008-0466en_US
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.openairetypeartículo-
item.grantfulltextopen-
item.cerifentitytypePublications-
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