Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/247919
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | An association analysis between polymorphisms of the pig solute carrier family 27A (SLC27A), member 1 and 4 genes and serum and muscle lipid traits |
Autor: | Melo, C.; Gallardo, David CSIC ORCID; Quintanilla, Raquel; Zidi, Ali; Castelló, Anna CSIC ORCID; Díaz, Isabel; Amills, Marcel CSIC ORCID; Pena, Ramona N. | Fecha de publicación: | 2013 | Editor: | Elsevier | Citación: | Livestock Science 152(2-3): 143-146 (2013) | Resumen: | Solute carrier family 27A (SLC27A) molecules play a fundamental role in the cellular uptake of long-chain fatty acids in a wide variety of tissues and organs. Although polymorphisms at the pig SLC27A1 and SLC27A4 genes have been associated with backfat thickness in pigs, the existence of associations with lipid composition traits has not been investigated yet. Herewith, we have sequenced the coding regions of the SLC27A1, SLC27A2 and SLC27A4 genes in 15 Duroc pigs, revealing the existence of three single nucleotide polymorphisms (SNP) at SLC27A1 (c.441C>T, c.747A>G and c.⁎400C>T) and two additional SNP at SLC27A4 (c.243T>G and c.837C>T). The performance of an association analysis with a wide array of serum and muscle lipid traits revealed the existence of suggestive associations (nominal P-value <0.05, but not significant after correction for multiple testing) between SLC27A1 genotype and gluteus medius saturated fatty acid (SFA) and stearic contents (%), and between SLC27A4 genotype and gluteus medius SFA content (%). Similarly, SLC27A1 genotype was suggestively associated with SFA content (%) at the longisimus thoracis et lumborum muscle. These findings agree from a functional point of view with the essential role of SLC27A family members in cellular fatty acid uptake and reinforce the need of further exploring the role of these molecules in defining muscle lipid composition. | Versión del editor: | https://doi.org/10.1016/j.livsci.2013.01.004 | URI: | http://hdl.handle.net/10261/247919 | DOI: | 10.1016/j.livsci.2013.01.004 | ISSN: | 1871-1413 |
Aparece en las colecciones: | (CRAG) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 59,24 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
7
checked on 26-mar-2024
WEB OF SCIENCETM
Citations
7
checked on 25-feb-2024
Page view(s)
52
checked on 28-mar-2024
Download(s)
10
checked on 28-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.