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Title

Hey1, a mediator of notch signaling, is an androgen receptor corepressor

AuthorsBelandia, Borja CSIC ORCID; García-Pedrero, Juana M.; Parker, Malcolm G.
Issue DateFeb-2005
PublisherAmerican Society for Microbiology
CitationMolecular and Cellular Biology 25(4): 1425-1436 (2005)
AbstractHey1 is a member of the basic helix-loop-helix-Orange family of transcriptional repressors that mediate Notch signaling. Here we show that transcription from androgen-dependent target genes is inhibited by Hey1 and that expression of a constitutively active form of Notch is capable of repressing transactivation by the endogenous androgen receptor (AR). Our results indicate that Hey1 functions as a corepressor for AF1 in the AR, providing a mechanism for cross talk between Notch and androgen-signaling pathways. Hey1 colocalizes with AR in the epithelia of patients with benign prostatic hyperplasia, where it is found in both the cytoplasm and the nucleus. In marked contrast, we demonstrate that Hey1 is excluded from the nucleus in most human prostate cancers, raising the possibility that an abnormal Hey1 subcellular distribution may have a role in the aberrant hormonal responses observed in prostate cancer.
Description12 pages, 9 figures, 1 table.-- et al.
Publisher version (URL)http://dx.doi.org/10.1128/MCB.25.4.1425-1436.2005
URIhttp://hdl.handle.net/10261/24706
DOI10.1128/MCB.25.4.1425-1436.2005
ISSN0270-7306
Appears in Collections:(IIBM) Artículos

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