Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/246322
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Convergent Evolution of Pain-Inducing Defensive Venom Components in Spitting Cobras |
Autor: | Kazandjian, Taline D.; Petras, D.; Robinson, S. D.; van Thiel, J.; Greene, Harry W.; Arbuckle, K.; Barlow, A.; Carter, D. A.; Wouters, R. M.; Whiteley, G.; Wagstaff, S. C.; Arias, A. S.; Albulescu, L.O.; Plettenberg Laing, A.; Hall, C.; Heap, A.; Penrhyn-Lowe, S.; McCabe, C. V.; Ainsworth, S.; da Silva, R. R.; Dorrestein, P. C.; Richardson, M. K.; Gutierrez, J. M.; Calvete, Juan J. CSIC ORCID; Harrison, Robert A.; Vetter, I.; Undheim, E. A. B.; Wuster, W.; Casewell, Nicholas R. | Fecha de publicación: | 10-jul-2020 | Editor: | BioRxiv | Citación: | Kazandjian, T.D.; Petras, D.; Robinson, S. D.; van Thiel, J.; Greene, H. W.; Arbuckle, K.; Barlow, A.; Carter, D. A.; Wouters, R. M.; Whiteley, G.; Wagstaff, S. C.; Arias, A. S.; Albulescu, L. O.; Plettenberg Laing, A.; Hall, C.; Heap, A.; Penrhyn-Lowe, S.; McCabe, C. V.; Ainsworth, S.; da Silva, R. R.; Dorrestein, P. C.; Richardson, M. K.; Gutierrez, J. M.; Calvete, Juan J. ; Harrison, R. A.; Vetter, I.; Undheim, E. A. B.; Wuster, W.; Casewell, N. R.; 2020; "Convergent Evolution of Pain-Inducing Defensive Venom Components in Spitting Cobras (Preprint)"; bioRxiv; 10.1101/2020.07.08.192443 | Resumen: | Convergent evolution provides unparalleled insights into the selective drivers underlying evolutionary change. While snakes use venom primarily for predation, and venom composition often reflects diet specificity, three lineages of spitting cobras have independently evolved the ability to use venom as a defensive projectile. Using gene, protein and functional analyses, we show that the three spitting lineages possess venom characterized by an upregulation of PLA2 toxins, which potentiate the action of venom cytotoxins to activate mammalian sensory neurons and cause enhanced pain. These repeated independent changes provide a fascinating example of convergent evolution across multiple phenotypic levels driven by exaptations. Notably, the timing of their origins suggests that defensive venom spitting may have evolved in response to the emergence of bipedal hominids in Africa and Asia. | Descripción: | Preprint 20 páginas. The molecular data associated with species tree generation have been deposited to the nucleotide database of NCBI and the accession numbers are displayed in Table S7. The transcriptome data have been deposited in the SRA and TSA databases of NCBI and are associated with the BioProject accession number PRJA506018. Mass spectrometry data and database search results for top-down and bottom-up proteomic experiments are publicly available in the MassIVE repository under accession number MSV000081885 and in proteomXchange with accession number PXD008597. | Versión del editor: | https://dx.doi.org/10.1101/2020.07.08.192443 | URI: | http://hdl.handle.net/10261/246322 | DOI: | 10.1101/2020.07.08.192443 | Referencias: | Kazandjian, T. D.; Petras, D.; Robinson, S. D.; van Thiel, J.; Greene, H. W.; Arbuckle, K.; Barlow, A.; Carter, D. A.; Wouters, R. M.; Whiteley, G.; Wagstaff, S. C.; Arias, A. S.; Albulescu, L. O.; Plettenberg Laing, A.; Hall, C.; Heap, A.; Penrhyn-Lowe, S.; McCabe, C. V.; Ainsworth, S.; da Silva, R. R.; Dorrestein, P. C.; Richardson, M. K.; Gutierrez, J. M.; Calvete, J. J.; Harrison, R. A.; Vetter, I.; Undheim, E. A. B.; Wuster, W.; Casewell, N. R. Convergent evolution of pain-inducing defensive venom components in spitting cobras. Science 371(6527):386-390 (2021). 10.1126/science.abb9303. http://hdl.handle.net/10261/246347 |
Aparece en las colecciones: | (IBV) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
2020 BioRxiv 192443.pdf | 424,52 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
70
checked on 18-abr-2024
Download(s)
106
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons