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Título: | Evolution, virulence and immunogenicity of relevant SARS-CoV-2 spike mutants |
Autor: | Coscollá, Mireia CSIC ORCID; Ruiz-Rodríguez, Paula CSIC ORCID ; Francés-Cuesta, Carlos CSIC ORCID; Geller, Ron CSIC ORCID ; Chiner-Oms, Álvaro CSIC ORCID ; Jiménez-Serrano, Santiago CSIC ORCID; Marina, Alberto CSIC ORCID ; Martínez-Priego, Llucia CSIC ORCID; D'Auria, Giuseppe; López, Mariana G. CSIC ORCID ; Cancino-Muñoz, Irving CSIC ORCID; Torres-Puente, Manuela CSIC ORCID ; Bracho, María Alma; Ruiz-Hueso, Paula; González-Candelas, Fernando CSIC ORCID; Comas, Iñaki CSIC ORCID | Fecha de publicación: | 9-jul-2021 | Citación: | 31st European Congress of Clinical Microbiology and Infectious Diseases (2021) | Resumen: | We have detected two mutations in the Spike protein of SARS-CoV-2 sequences at amino acid positions 1163 and 1167 which appeared independently in multiple transmission clusters and different genetic backgrounds, indicating they may increase viral fitness. Both mutations appeared together in a cluster within clade 20E. This cluster is characterized by 12 additional single nucleotide polymorphisms but no deletions. The available structural information of the S protein in the preand post-fusion conformations we predict that both mutations confer rigidity, that potentially could decrease viral fitness. Despite the multiple and successful appearance of two HR2 mutations during the first year of SARS-CoV-2 evolution, in vi tro stability, infectivi ty, or antibody escape does not seem to play a role. | Descripción: | SeqCOVm-SPAIN consortium. Trabajo presentado al 31st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), celebrado online del 9 al 12 de julio de 2021. |
URI: | http://hdl.handle.net/10261/245721 |
Aparece en las colecciones: | (IBV) Comunicaciones congresos (I2SysBio) Comunicaciones congresos (PTI Salud Global) Colección Especial COVID-19 |
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2021 Comas ECCMID_Evol Virul.pdf | 5,29 MB | Adobe PDF | Visualizar/Abrir |
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