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Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo

AutorPeinado, Héctor; Marín, Faustino; Cubillo, Eva ; Nieto, M. Ángela ; Cano, Amparo
Palabras claveSnail
E47
E-cadherin
Invasion
Angiogenesis
Transplantation assays
Fecha de publicación1-jun-2004
EditorCompany of Biologists
CitaciónJournal of Cell Science 117(13): 2827-2839 (2004)
ResumenThe transcription factors Snail and E47 are direct repressors of E-cadherin, with both inducing a full epithelial-mesenchymal transition and invasive behaviour in vitro when expressed in the prototypic epithelial MDCK cell line. The role of these repressors in the invasive process and in other tumorigenic properties is, nevertheless, still poorly understood. However, organotypic cultures and in vivo transplantation assays indicate that cells expressing MDCK-Snail and MDCK-E47 exhibit significant differences. MDCK-Snail cells have a higher infiltrative potential than MDCK-E47 cells. Interestingly, both cell types induce angiogenesis of the host stromal tissue in transplantation assays, but this property is greatly enhanced in transplants of MDCK-E47 cells. Xenografted tumours induced in nude mice also show signs of strong angiogenic potential, again markedly increased in tumours induced by MDCK-E47 which exhibit a higher vessel density and proliferation rate than those induced by MDCK-Snail cells. These results suggest differential roles for Snail and E47 E-cadherin repressors in tumour progression where Snail is implicated in promoting the initial invasion and E47 plays an active role in tumour cell growth by promoting angiogenesis.
Descripción13 páginas, 7 figuras.-- et al.
Versión del editorhttp://dx.doi.org/10.1242/jcs.01145
URIhttp://hdl.handle.net/10261/24570
DOI10.1242/jcs.01145
ISSN0021-9533
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