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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/24559
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dc.contributor.authorKester, Monique H. A.-
dc.contributor.authorMartínez de Mena, Raquel-
dc.contributor.authorObregón, María Jesús-
dc.contributor.authorHume, Robert-
dc.contributor.authorMorreale de Escobar, Gabriella-
dc.date.accessioned2010-05-21T08:34:57Z-
dc.date.available2010-05-21T08:34:57Z-
dc.date.issued2004-07-
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism 89(7): 3117-3128 (2004)en_US
dc.identifier.issn0021-972X-
dc.identifier.urihttp://hdl.handle.net/10261/24559-
dc.description12 pages, 8 figures, 3 tables.-- et al.en_US
dc.description.abstractThyroid hormones are required for human brain development, but data on local regulation are limited. We describe the ontogenic changes in T(4), T(3), and rT(3) and in the activities of the types I, II, and III iodothyronine deiodinases (D1, D2, and D3) in different brain regions in normal fetuses (13-20 wk postmenstrual age) and premature infants (24-42 wk postmenstrual age). D1 activity was undetectable. The developmental changes in the concentrations of the iodothyronines and D2 and D3 activities showed spatial and temporal specificity but with divergence in the cerebral cortex and cerebellum. T(3) increased in the cortex between 13 and 20 wk to levels higher than adults, unexpected given the low circulating T(3). Considerable D2 activity was found in the cortex, which correlated positively with T(4) (r = 0.65). Cortex D3 activity was very low, as was D3 activity in germinal eminence and choroid plexus. In contrast, cerebellar T(3) was very low and increased only after midgestation. Cerebellum D3 activities were the highest (64 fmol/min.mg) of the regions studied, decreasing after midgestation. Other regions with high D3 activities (midbrain, basal ganglia, brain stem, spinal cord, hippocampus) also had low T(3) until D3 started decreasing after midgestation. D3 was correlated with T(3) (r = -0.682) and rT(3)/T(3) (r = 0.812) and rT(3)/T(4) (r = 0.889). Our data support the hypothesis that T(3) is required by the human cerebral cortex before midgestation, when mother is the only source of T(4). D2 and D3 play important roles in the local bioavailability of T(3). T(3) is produced from T(4) by D2, and D3 protects brain regions from excessive T(3) until differentiation is required.en_US
dc.description.sponsorshipThis work was supported by European Community Grant QLG-2000-00930, Netherlands Organization for Scientific Research Grant 903-40-204, Fondo de Investigacion Sanitaria RCMN (C03/08) from Inst. de Salud Carlos III, Chief Scientists Office Scottish Executive (K/MRS/50/C741), and Tenovus Scotland/Leng Trust.en_US
dc.format.extent563343 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherEndocrine Societyen_US
dc.rightsopenAccessen_US
dc.titleIodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areasen_US
dc.typeartículoen_US
dc.identifier.doi10.1210/jc.2003-031832-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1210/jc.2003-031832en_US
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.openairetypeartículo-
item.languageiso639-1en-
item.grantfulltextopen-
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