Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/24548
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Ausó Monreal, Eva | - |
dc.contributor.author | Lavado Autric, Rosalía | - |
dc.contributor.author | Cuevas, Estela | - |
dc.contributor.author | Escobar del Rey, Francisco | - |
dc.contributor.author | Morreale de Escobar, Gabriella | - |
dc.contributor.author | Berbel, Pere | - |
dc.date.accessioned | 2010-05-20T12:32:49Z | - |
dc.date.available | 2010-05-20T12:32:49Z | - |
dc.date.issued | 2004-09 | - |
dc.identifier.citation | Endocrinology 145(9): 4037-4047 (2004) | en_US |
dc.identifier.issn | 0013-7227 | - |
dc.identifier.uri | http://hdl.handle.net/10261/24548 | - |
dc.description | 11 pages, 6 figures, 1 table. | en_US |
dc.description.abstract | Epidemiological studies and case reports show that even a relatively minor degree of maternal hypothyroxinemia during the first half of gestation is potentially dangerous for optimal fetal neurodevelopment. Our experimental approach was designed to result in a mild and transient period of maternal hypothyroxinemia at the beginning of corticogenesis. Normal rat dams received the goitrogen 2-mercapto-1-methyl-imidazole for only 3 d, from embryonic d 12 (E12) to E15. Maternal thyroid hormones decreased transiently to 70% of normal serum values, without clinical signs of hypothyroidism. Dams were injected daily with 5-bromo-2'-deoxyuridine (BrdU) during 3 d, from E14-E16 or E17-E19. Their pups were tested for audiogenic seizure susceptibility 39 d after birth (P39) and killed at P40. Cells that had incorporated BrdU were identified by immunocytochemistry, and quantified: numerous heterotopic cells were found, whether labeled at E14-E16 or E17-E19, that were identified as neurons. The cytoarchitecture and the radial distribution of BrdU-labeled neurons was significantly affected in the somatosensory cortex and hippocampus of 83% of the pups. The radial distribution of gamma-aminobutyric acidergic neurons was, however, normal. The infusion of dams with T4 between E13 and E15 avoided these alterations, which were not prevented when the T4 infusion was delayed to E15-E18. In total, 52% of the pups born to the goitrogen-treated dams responded to an acoustic stimulus with wild runs, followed in some by seizures. When extrapolated to man, these results stress the need for prevention of hypothyroxinemia before midpregnancy, however moderate, and whichever the underlying cause. | en_US |
dc.description.sponsorship | This work was supported by Spanish Grants from Comisión Interministerial de Ciencia y Tecnología SAF2000-0152-C02-01 and Instituto de Salud Carlos III PI030576 (to P.B.), and Comunidad Autónoma de Madrid 08.5/0059.1/2000 and Instituto de Salud Carlos III Red de Centros Metabolismo y Nutricion C03-08 (to G.M.d.E.). E.C. was the recipient of fellowship no. 124841 of the Consejo Nacíonal de Ciencía y Tecnología from México. | en_US |
dc.format.extent | 722530 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | Endocrine Society | en_US |
dc.rights | openAccess | en_US |
dc.title | A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1210/en.2004-0274 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1210/en.2004-0274 | en_US |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IN) Artículos (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
A moderate and transient.pdf | 705,6 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
390
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
324
checked on 25-feb-2024
Page view(s)
563
checked on 23-abr-2024
Download(s)
450
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.