Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/24548
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration

AuthorsAusó Monreal, Eva; Lavado Autric, Rosalía; Cuevas, Estela; Escobar del Rey, Francisco; Morreale de Escobar, Gabriella CSIC ; Berbel, Pere
Issue DateSep-2004
PublisherEndocrine Society
CitationEndocrinology 145(9): 4037-4047 (2004)
AbstractEpidemiological studies and case reports show that even a relatively minor degree of maternal hypothyroxinemia during the first half of gestation is potentially dangerous for optimal fetal neurodevelopment. Our experimental approach was designed to result in a mild and transient period of maternal hypothyroxinemia at the beginning of corticogenesis. Normal rat dams received the goitrogen 2-mercapto-1-methyl-imidazole for only 3 d, from embryonic d 12 (E12) to E15. Maternal thyroid hormones decreased transiently to 70% of normal serum values, without clinical signs of hypothyroidism. Dams were injected daily with 5-bromo-2'-deoxyuridine (BrdU) during 3 d, from E14-E16 or E17-E19. Their pups were tested for audiogenic seizure susceptibility 39 d after birth (P39) and killed at P40. Cells that had incorporated BrdU were identified by immunocytochemistry, and quantified: numerous heterotopic cells were found, whether labeled at E14-E16 or E17-E19, that were identified as neurons. The cytoarchitecture and the radial distribution of BrdU-labeled neurons was significantly affected in the somatosensory cortex and hippocampus of 83% of the pups. The radial distribution of gamma-aminobutyric acidergic neurons was, however, normal. The infusion of dams with T4 between E13 and E15 avoided these alterations, which were not prevented when the T4 infusion was delayed to E15-E18. In total, 52% of the pups born to the goitrogen-treated dams responded to an acoustic stimulus with wild runs, followed in some by seizures. When extrapolated to man, these results stress the need for prevention of hypothyroxinemia before midpregnancy, however moderate, and whichever the underlying cause.
Description11 pages, 6 figures, 1 table.
Publisher version (URL)http://dx.doi.org/10.1210/en.2004-0274
URIhttp://hdl.handle.net/10261/24548
DOI10.1210/en.2004-0274
ISSN0013-7227
Appears in Collections:(IN) Artículos
(IIBM) Artículos

Files in This Item:
File Description SizeFormat
A moderate and transient.pdf705,6 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

SCOPUSTM   
Citations

365
checked on May 16, 2022

WEB OF SCIENCETM
Citations

307
checked on May 12, 2022

Page view(s)

508
checked on May 21, 2022

Download(s)

322
checked on May 21, 2022

Google ScholarTM

Check

Altmetric

Dimensions


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.