Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/245110
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms |
Autor: | Lisa, Silvia CSIC; Domingo, Beatriz; Martínez, Javier CSIC ORCID; Gilch, Sabine; Llopis, J. F.; Schätzl, Hermann M. | Fecha de publicación: | 2012 | Editor: | American Society for Biochemistry and Molecular Biology | Citación: | Journal of Biological Chemistry 287: 36693-36701 (2012) | Resumen: | Background: In vivo folding could play an essential role in prion neurodegenerations. Results: Artificial mutants causing labile PrP folds when expressed in cells originate toxic CtmPrP featured by the absence of the intramolecular disulfide bond. Conclusion: Oxidative folding impairment facilitates the formation of the toxic PrP forms. Significance: Unveiling the mechanism facilitating the formation of toxic PrP forms is crucial for the understanding and prevention of prion disorders. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc. | Descripción: | This article has been withdrawn (November 15, 2017) | Versión del editor: | http://dx.doi.org/10.1074/jbc.M112.398776 | URI: | http://hdl.handle.net/10261/245110 | DOI: | 10.1074/jbc.M112.398776 | Identificadores: | doi: 10.1074/jbc.M112.398776 issn: 0021-9258 |
Aparece en las colecciones: | (IQF) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
59
checked on 23-abr-2024
Download(s)
9
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons