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Title

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome

AuthorsLafarga, Miguel; Berciano, María T.; Pena, Emma; Mayo, Isabel; Castaño, José G.; Bohmann, Dirk; Rodrigues, João Pedro; Tavanez, João Paulo; Carmo-Fonseca, Maria
Issue DateAug-2002
PublisherAmerican Society for Cell Biology
CitationMolecular Biology of the Cell 13(8): 2771-2782 (2002)
AbstractNuclear bodies represent a heterogeneous class of nuclear structures. Herein, we describe that a subset of nuclear bodies is highly enriched in components of the ubiquitin-proteasome pathway of proteolysis. We coined the term clastosome (from the Greek klastos, broken and soma, body) to refer to this type of nuclear body. Clastosomes contain a high concentration of 1) ubiquitin conjugates, 2) the proteolytically active 20S core and the 19S regulatory complexes of the 26S proteasome, and 3) protein substrates of the proteasome. Although detected in a variety of cell types, clastosomes are scarce under normal conditions; however, they become more abundant when proteasomal activity is stimulated. In contrast, clastosomes disappear when cells are treated with proteasome inhibitors. Protein substrates of the proteasome that are found concentrated in clastosomes include the short-lived transcription factors c-Fos and c-Jun, adenovirus E1A proteins, and the PML protein. We propose that clastosomes are sites where proteolysis of a variety of protein substrates is taking place.
Description12 páginas, 9 figuras.
Publisher version (URL)http://dx.doi.org/10.1091/mbc.E02-03-0122
URIhttp://hdl.handle.net/10261/24494
DOI10.1091/mbc.E02-03-0122
ISSN1059-1524
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