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http://hdl.handle.net/10261/244876
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dc.contributor.author | Rodríguez-Otero, Paula | - |
dc.contributor.author | Mateos, Maria Victoria | - |
dc.contributor.author | Martínez-López, Joaquín | - |
dc.contributor.author | Martín-Calvo, Nerea | - |
dc.contributor.author | Hernandez, Miguel T. | - |
dc.contributor.author | Ocio, Enrique M. | - |
dc.contributor.author | Rosiñol, Laura | - |
dc.contributor.author | Martínez, Rafael | - |
dc.contributor.author | Teruel, Ana-Isabel | - |
dc.contributor.author | Gutiérrez, Norma Carmen | - |
dc.contributor.author | Bargay, Joan | - |
dc.contributor.author | Bengoechea, Óscar | - |
dc.contributor.author | González, Yolanda | - |
dc.contributor.author | Pérez de Oteyza, Jaime | - |
dc.contributor.author | Gironella, Mercedes | - |
dc.contributor.author | Encinas, Cristina | - |
dc.contributor.author | Martín, Jesús | - |
dc.contributor.author | Cabrera, Carmen | - |
dc.contributor.author | Palomera, Luis | - |
dc.contributor.author | Arriba, Felipe de | - |
dc.contributor.author | Cedena, Maria-Teresa | - |
dc.contributor.author | Paiva, Bruno | - |
dc.contributor.author | Puig, Noemi | - |
dc.contributor.author | Oriol, Albert | - |
dc.contributor.author | Bladé, Joan | - |
dc.contributor.author | Lahuerta, Juan José | - |
dc.contributor.author | Miguel, Jesus F. San | - |
dc.date.accessioned | 2021-06-29T09:40:10Z | - |
dc.date.available | 2021-06-29T09:40:10Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Leukemia 32: 2427-2434 (2018) | - |
dc.identifier.issn | 0887-6924 | - |
dc.identifier.uri | http://hdl.handle.net/10261/244876 | - |
dc.description.abstract | Although survival of elderly myeloma patients has significantly improved there is still a subset of patients who, despite being fit and achieving optimal responses, will die within 2 years of diagnosis due to myeloma progression. The objective of this study was to define a scoring prognostic index to identify this group of patients. We have evaluated the outcome of 490 newly diagnosed elderly myeloma patients included in two Spanish trials (GEM2005-GEM2010). Sixty-eight patients (13.8%) died within 2 years of diagnosis (early deaths) due to myeloma progression. Our study shows that the use of simple scoring model based on 4 widely available markers (elevated LDH, ISS 3, high risk CA or >75 years) can contribute to identify up-front these patients. Moreover, unsustained response (<6 months duration) emerged as one important predictor of early myeloma-related mortality associated with a significant increase in the risk of death related to myeloma progression. The identification of these patients at high risk of early death is relevant for innovative trials aiming to maintain the depth of first response, since many of them will not receive subsequent lines of therapy. | - |
dc.description.sponsorship | This study was supported by the Cooperative Research Thematic Networkgrants RD12/0036/0058 and RD12/0036/0046 of the Redde Cancer (Cancer Network of Excellence); Instituto deSalud Carlos III, Spain, Instituto de Salud Carlos III/SubdirecciónGeneral de Investigación Sanitaria part-financedby the European Regional Development Fund (FIS: PI12/01761; PI12/02311; PI13/01469; PI14/01867, G03/136;Sara Borrell: CD13/00340); Asociación Española Contra el Cáncer (GCB120981SAN) and FEDER. | - |
dc.language | eng | - |
dc.publisher | Springer Nature | - |
dc.rights | closedAccess | - |
dc.subject | Epidemiology | - |
dc.subject | Risk factors | - |
dc.title | Early myeloma-related death in elderly patients: development of a clinical prognostic score and evaluation of response sustainability role | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1038/s41375-018-0072-6 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1038/s41375-018-0072-6 | - |
dc.identifier.e-issn | 1476-5551 | - |
dc.date.updated | 2021-06-29T09:40:10Z | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Asociación Española Contra el Cáncer | - |
dc.contributor.funder | European Commission | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
Aparece en las colecciones: | (IBMCC) Artículos |
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