English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/24484
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
 |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability

AutorSánchez-Pérez, Isabel; Aznar, Salvador; Martínez-Gomariz, Montserrat; Lacal, Juan Carlos ; Perona Abellón, Rosario
Fecha de publicaciónago-2002
EditorAmerican Society for Cell Biology
CitaciónMolecular Biology of the Cell 13(8): 2933-2045 (2002)
ResumenChemotherapeutic agents such as cisplatin induce persistent activation of N-terminal c-Jun Kinase, which in turn mediates induction of apoptosis. By using a common MAPK Kinase, MEKK1, cisplatin also activates the survival transcription factor NFkappaB. We have found a cross-talk between c-Jun expression and NFkappaB transcriptional activation in response to cisplatin. Fibroblast derived from c-jun knock out mice are more resistant to cisplatin-induced cell death, and this survival advantage is mediated by upregulation of NFkappaB-dependent transcription and expression of MIAP3. This process can be reverted by ectopic expression of c-Jun in c-jun(-/-) fibroblasts, which decreases p65 transcriptional activity back to normal levels. Negative regulation of NFkappaB-dependent transcription by c-jun contributes to cisplatin-induced cell death, which suggests that inhibition of NFkappaB may potentiate the antineoplastic effect of conventional chemotherapeutic agents.
Descripción13 pages, 11 figures.
Versión del editorhttp://dx.doi.org/10.1091/mbc.E02–01–0022.
URIhttp://hdl.handle.net/10261/24484
DOI10.1091/mbc.E02–01–0022
ISSN1059-1524
Aparece en las colecciones: (IIBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
2933.pdf398,32 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.