Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/24484
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability |
Autor: | Sánchez-Pérez, Isabel CSIC ORCID; Aznar, Salvador CSIC ORCID; Martínez-Gomariz, Montserrat; Lacal, Juan Carlos CSIC ORCID; Perona Abellón, Rosario CSIC ORCID | Fecha de publicación: | ago-2002 | Editor: | American Society for Cell Biology | Citación: | Molecular Biology of the Cell 13(8): 2933-2045 (2002) | Resumen: | Chemotherapeutic agents such as cisplatin induce persistent activation of N-terminal c-Jun Kinase, which in turn mediates induction of apoptosis. By using a common MAPK Kinase, MEKK1, cisplatin also activates the survival transcription factor NFkappaB. We have found a cross-talk between c-Jun expression and NFkappaB transcriptional activation in response to cisplatin. Fibroblast derived from c-jun knock out mice are more resistant to cisplatin-induced cell death, and this survival advantage is mediated by upregulation of NFkappaB-dependent transcription and expression of MIAP3. This process can be reverted by ectopic expression of c-Jun in c-jun(-/-) fibroblasts, which decreases p65 transcriptional activity back to normal levels. Negative regulation of NFkappaB-dependent transcription by c-jun contributes to cisplatin-induced cell death, which suggests that inhibition of NFkappaB may potentiate the antineoplastic effect of conventional chemotherapeutic agents. | Descripción: | 13 pages, 11 figures. | Versión del editor: | http://dx.doi.org/10.1091/mbc.E02–01–0022. | URI: | http://hdl.handle.net/10261/24484 | DOI: | 10.1091/mbc.E02–01–0022 | ISSN: | 1059-1524 |
Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
2933.pdf | 398,32 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
338
checked on 23-abr-2024
Download(s)
280
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.