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Título: | Cereblon gene expression and correlation with clinical outcomes in patients with relapsed/refractory multiple myeloma treated with pomalidomide: an analysis of STRATUS |
Autor: | Qian, Xiaozhong; Dimopoulos, Meletios A.; Amateangelo, Michael; Bjorklund, Chad; Towfic, Fadi; Flynt, Erin; Weisel, Katja C.; Ocio, Enrique M. CSIC ORCID ; Peluso, Teresa; Sternas, Lars; Zaki, Mohamed H.; Moreau, Philippe; Thakurta, Anjan | Palabras clave: | Multiple myeloma Biomarkers Pomalidomide Cereblon Immunomodulatory agents |
Fecha de publicación: | 2018 | Editor: | Taylor & Francis | Citación: | Leukemia and Lymphoma 60(2): 462-470 (2018) | Resumen: | We analyzed gene expression levels of CRBN, cMYC, IRF4, BLIMP1, and XBP1 in 224 patients with multiple myeloma treated with pomalidomide and low-dose dexamethasone in the STRATUS study (ClinicalTrials.gov: NCT01712789; EudraCT number: 2012-001888-78). Clinical responses were observed at all CRBN expression levels. A trend in progression-free survival (PFS; p = .038) and a potential trend in overall survival (OS; p = .059) favoring high CRBN expressers were observed; however, no notable difference in overall response rate (ORR) was observed. ORR (30%), median PFS (17.7 weeks), and median OS (52.3 weeks) in low-CRBN expressers were comparable to those in the STRATUS intent-to-treat population (ORR, 33%; median PFS, 20.0 weeks; median OS, 51.7 weeks). A trend in ORR (p = .050) favoring higher cMYC expressers was observed with no notable difference in PFS or OS. This analysis does not support exploring CRBN as a biomarker for selecting patients for pomalidomide therapy. | Versión del editor: | http://dx.doi.org/10.1080/10428194.2018.1485915 | URI: | http://hdl.handle.net/10261/244837 | DOI: | 10.1080/10428194.2018.1485915 | ISSN: | 1042-8194 | E-ISSN: | 1029-2403 |
Aparece en las colecciones: | (IBMCC) Artículos |
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