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Title

Protection by nitric oxide against liver inflammatory injury in animals carrying a nitric oxide synthase-2 transgene

AuthorsMojena, Marina; Hortelano, Sonsoles; Castrillo, Antonio CSIC; Díaz-Guerra, María José; García-Barchino, María J.; Sáez, Guillermo T.; Boscá, Lisardo CSIC ORCID CVN
KeywordsLiver cells
Lipopolysaccharide
Issue DateMar-2001
PublisherFederation of American Societies for Experimental Biology
CitationFaseb Journal 15(3): 583-585 (2001)
AbstractThe effect of pre-existent hepatic NO synthesis on liver injury induced by lipopolysaccharide was studied in animals carrying a nitric oxide synthase-2 (NOS-2) transgene under the control of the phosphoenolpyruvate carboxykinase (PEPCK) promoter. These animals expressed NOS-2 in liver cells under fasting conditions. Lipopolysaccharide-induced liver injury in D-galactosamine-conditioned mice, which enhanced notably the effect of the endotoxin on the liver, was impaired in animals expressing NOS-2. This protection against inflammatory liver damage was dependent on NO synthesis and was caused by an inhibition of nuclear factor kB (NF-kB) activity and an impairment of the synthesis of the proinflammatory cytokines tumor necrosis factor a and interleukin 1b. These data indicate that intrahepatic synthesis of NO protects liver by inhibiting the release of cascades of proinflammatory mediators and suggest a beneficial role for local delivery of NO in the control of liver injury.
Description22 pages, 7 figures, 1 table.
Publisher version (URL)http://dx.doi.org/10.1096/fj.00-0509fje
URIhttp://hdl.handle.net/10261/24464
DOI10.1096/fj.00-0509fje
ISSN0892-6638
Appears in Collections:(IIBM) Artículos




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