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Title: | Protection by nitric oxide against liver inflammatory injury in animals carrying a nitric oxide synthase-2 transgene |
Authors: | Mojena, Marina; Hortelano, Sonsoles; Castrillo, Antonio CSIC; Díaz-Guerra, María José; García-Barchino, María J.; Sáez, Guillermo T.; Boscá, Lisardo CSIC ORCID CVN | Keywords: | Liver cells Lipopolysaccharide |
Issue Date: | Mar-2001 | Publisher: | Federation of American Societies for Experimental Biology | Citation: | Faseb Journal 15(3): 583-585 (2001) | Abstract: | The effect of pre-existent hepatic NO synthesis on liver injury induced by lipopolysaccharide was studied in animals carrying a nitric oxide synthase-2 (NOS-2) transgene under the control of the phosphoenolpyruvate carboxykinase (PEPCK) promoter. These animals expressed NOS-2 in liver cells under fasting conditions. Lipopolysaccharide-induced liver injury in D-galactosamine-conditioned mice, which enhanced notably the effect of the endotoxin on the liver, was impaired in animals expressing NOS-2. This protection against inflammatory liver damage was dependent on NO synthesis and was caused by an inhibition of nuclear factor kB (NF-kB) activity and an impairment of the synthesis of the proinflammatory cytokines tumor necrosis factor a and interleukin 1b. These data indicate that intrahepatic synthesis of NO protects liver by inhibiting the release of cascades of proinflammatory mediators and suggest a beneficial role for local delivery of NO in the control of liver injury. | Description: | 22 pages, 7 figures, 1 table. | Publisher version (URL): | http://dx.doi.org/10.1096/fj.00-0509fje | URI: | http://hdl.handle.net/10261/24464 | DOI: | 10.1096/fj.00-0509fje | ISSN: | 0892-6638 |
Appears in Collections: | (IIBM) Artículos |
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