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dc.contributor.authorRuiz-Santaquiteria, Martaes_ES
dc.contributor.authorIllescas, Beatriz M.es_ES
dc.contributor.authorAbdelnabi, Ranaes_ES
dc.contributor.authorBoonen, Arnaudes_ES
dc.contributor.authorMills, Albertoes_ES
dc.contributor.authorMartí-Marí, Olaiaes_ES
dc.contributor.authorNoppen, Sames_ES
dc.contributor.authorNeyts, Johanes_ES
dc.contributor.authorSchols, Dominiquees_ES
dc.contributor.authorGago, Federicoes_ES
dc.contributor.authorSan-Félix, Anaes_ES
dc.contributor.authorCamarasa Rius, María-Josées_ES
dc.contributor.authorMartín, Nazarioes_ES
dc.date.accessioned2021-06-24T10:29:32Z-
dc.date.available2021-06-24T10:29:32Z-
dc.date.issued2021-04-14-
dc.identifier.citationChemistry—A European Journal 27 : 1–12 (2021)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/244578-
dc.description.abstractUnprecedented 3D hexa-adducts of [60]fullerene peripherally decorated with twelve tryptophan (Trp) or tyrosine (Tyr) residues have been synthesized. Studies on the antiviral activity of these novel compounds against HIV and EV71 reveal that they are much more potent against HIV and equally active against EV71 than the previously described dendrimer prototypes AL-385 and AL-463, which possess the same number of Trp/Tyr residues on the periphery but attached to a smaller and more flexible pentaerythritol core. These results demonstrate the relevance of the globular 3D presentation of the peripheral groups (Trp/Tyr) as well as the length of the spacer connecting them to the central core to interact with the viral envelopes, particularly in the case of HIV, and support the hypothesis that [60]fullerene can be an alternative and attractive biocompatible carbon-based scaffold for this type of highly symmetrical dendrimers. In addition, the functionalized fullerenes here described, which display twelve peripheral negatively charged indole moieties on their globular surface, define a new and versatile class of compounds with a promising potential in biomedical applications.es_ES
dc.description.sponsorshipThis work has been supported by the Spanish MINECO/FEDER (Projects CTQ2017-84327-P and CTQ2017-83531-R), the Spanish MICINN (Projects PID2019-104070RB-C21 and PID2019- 104070RB-C22), the Spanish Agencia Estatal Consejo Superior de Investigaciones Científicas (CSIC, Projects CSIC-PIE- 201980E100 and CSIC-PIE-201980E028), “The Centers of Excellence” of the KU Leuven (EF-05/15 and PF-10/18), EU FP7 (FP7/ 2007–2013) Project EUVIRNA (Grant 408 Agreement 264286), EU FP7 SILVER (Contract HEALTH-F3-2010-260644), a grant from the Belgian Interuniversity Attraction Poles (IAP) Phase VII-P7/45 (BELVIR) and the EU FP7 Industry-Academia Partnerships and Pathways Project AIROPICO. The Spanish MEC/MINECO is also acknowledged for a grant to O. M.-M. We also thank Charlotte Vanderheydt, Caroline Collard, Kim Donckers, Sandra Claes and Evelyne Van Kerckhove for help with the processing of the antiviral data.es_ES
dc.language.isoenges_ES
dc.publisherWiley-VCHes_ES
dc.relationMICIU/ICTI2017-2020/CTQ2017-84327-Pes_ES
dc.relationMICIU/ICTI2017-2020/CTQ2017-83531-Res_ES
dc.relationMICIU/ICTI2017-2020/PID2019-104070RB-C21es_ES
dc.relationMICIU/ICTI2017-2020/PID2019- 104070RB-C22es_ES
dc.relationeu-repo/grantAgreement/EC/FP7/264286es_ES
dc.relationHEALTH-F3-2010-260644es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectAntiviral agentses_ES
dc.subjectEV71es_ES
dc.subjectFullereneses_ES
dc.subjectHexa-adductes_ES
dc.subjectHIVes_ES
dc.titleMultivalent Tryptophan- and Tyrosine-Containing [60] Fullerene Hexa-Adducts as Dual HIV and Enterovirus A71 Entry Inhibitorses_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.1002/chem.202101098-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1002/chem.202101098es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.contributor.orcidSan-Félix, Ana [0000-0003-4271-7598]es_ES
dc.contributor.orcidCamarasa, María-José [0000-0002-4978-6468]es_ES
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