English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/244578
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Multivalent Tryptophan- and Tyrosine-Containing [60] Fullerene Hexa-Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors

AuthorsRuiz-Santaquiteria, Marta CSIC ORCID; Illescas, Beatriz M.; Abdelnabi, Rana; Boonen, Arnaud; Mills, Alberto; Martí-Marí, Olaia; Noppen, Sam; Neyts, Johan; Schols, Dominique; Gago, Federico CSIC ORCID; San-Félix, Ana CSIC ORCID CVN ; Camarasa Rius, María-José; Martín, Nazario
KeywordsAntiviral agents
Issue Date14-Apr-2021
CitationChemistry—A European Journal 27 : 1–12 (2021)
AbstractUnprecedented 3D hexa-adducts of [60]fullerene peripherally decorated with twelve tryptophan (Trp) or tyrosine (Tyr) residues have been synthesized. Studies on the antiviral activity of these novel compounds against HIV and EV71 reveal that they are much more potent against HIV and equally active against EV71 than the previously described dendrimer prototypes AL-385 and AL-463, which possess the same number of Trp/Tyr residues on the periphery but attached to a smaller and more flexible pentaerythritol core. These results demonstrate the relevance of the globular 3D presentation of the peripheral groups (Trp/Tyr) as well as the length of the spacer connecting them to the central core to interact with the viral envelopes, particularly in the case of HIV, and support the hypothesis that [60]fullerene can be an alternative and attractive biocompatible carbon-based scaffold for this type of highly symmetrical dendrimers. In addition, the functionalized fullerenes here described, which display twelve peripheral negatively charged indole moieties on their globular surface, define a new and versatile class of compounds with a promising potential in biomedical applications.
Publisher version (URL)https://doi.org/10.1002/chem.202101098
Appears in Collections:(IQM) Artículos
Files in This Item:
File Description SizeFormat 
chem.202101098.pdfArtículo principal5,15 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.