Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/24437

COMPARTIR / EXPORTAR:

SHARE BASE	Comparte tu historia de Acceso Abierto
Visualizar otros formatos: MARC \| Dublin Core \| RDF \| ORE \| MODS \| METS \| DIDL \| DATACITE
Refman EndNote Bibtex RefWorks Excel CSV PDF DataCite Send via email

Título:	Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism
Autor:	Vincent, Olivier CSIC ORCID ; Carlson, Marian
Palabras clave:	Snf1/AMPK kinases Yeast Nuclear localization Glucose signaling
Fecha de publicación:	1-may-2001
Editor:	Cold Spring Harbor Laboratory Press
Citación:	Genes and Development 15(9): 1104-1114 (2001)
Resumen:	The Snf1/AMP-activated protein kinase family has broad roles in transcriptional, metabolic, and developmental regulation in response to stress. In Saccharomyces cerevisiae, Snf1 is required for the response to glucose limitation. Snf1 kinase complexes contain the alpha (catalytic) subunit Snf1, one of the three related beta subunits Gal83, Sip1, or Sip2, and the gamma subunit Snf4. We present evidence that the beta subunits regulate the subcellular localization of the Snf1 kinase. Green fluorescent protein fusions to Gal83, Sip1, and Sip2 show different patterns of localization to the nucleus, vacuole, and/or cytoplasm. We show that Gal83 directs Snf1 to the nucleus in a glucose-regulated manner. We further identify a novel signaling pathway that controls this nuclear localization in response to glucose phosphorylation. This pathway is distinct from the glucose signaling pathway that inhibits Snf1 kinase activity and responds not only to glucose but also to galactose and sucrose. Such independent regulation of the localization and the activity of the Snf1 kinase, combined with the distinct localization of kinases containing different beta subunits, affords versatility in regulating physiological responses.
Descripción:	12 pages, 8 figures, 1 table.-- et al.
Versión del editor:	http://genesdev.cshlp.org/content/15/9/1104.long
URI:	http://hdl.handle.net/10261/24437
ISSN:	0890-9369
Aparece en las colecciones:	(IIBM) Artículos