Thyroid hormone regulates reelin and dab1 expression during brain development

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dc.contributor.author	Álvarez-Dolado, Manuel	-
dc.contributor.author	Bernal, Juan	-
dc.contributor.author	Muñoz Terol, Alberto	-
dc.date.accessioned	2010-05-18T07:29:46Z	-
dc.date.available	2010-05-18T07:29:46Z	-
dc.date.issued	1999-08-15	-
dc.identifier.citation	Journal of Neuroscience 19(16): 6979-6993 (1999)	en_US
dc.identifier.issn	1529-2401	-
dc.identifier.uri	http://hdl.handle.net/10261/24405	-
dc.description	15 pages, 11 figures.-- et al.	en_US
dc.description.abstract	The reelin and dab1 genes are necessary for appropriate neuronal migration and lamination during brain development. Since these processes are controlled by thyroid hormone, we studied the effect of thyroid hormone deprivation and administration on the expression of reelin and dab1. As shown by Northern analysis, in situ hybridization, and immunohistochemistry studies, hypothyroid rats expressed decreased levels of reelin RNA and protein during the perinatal period [embryonic day 18 (E18) and postnatal day 0 (P0)]. The effect was evident in Cajal-Retzius cells of cortex layer I, as well as in layers V/VI, hippocampus, and granular neurons of the cerebellum. At later ages, however, Reelin was more abundant in the cortex, hippocampus, cerebellum, and olfactory bulb of hypothyroid rats (P5), and no differences were detected at P15. Conversely, Dab1 levels were higher at P0, and lower at P5 in hypothyroid animals. In line with these results, reelin RNA and protein levels were higher in cultured hippocampal slices from P0 control rats compared to those from hypothyroid animals. Significantly, thyroid-dependent regulation of reelin and dab1 was confirmed in vivo and in vitro by hormone treatment of hypothyroid rats and organotypic cultures, respectively. In both cases, thyroid hormone led to an increase in reelin expression. Our data suggest that the effects of thyroid hormone on neuronal migration may be in part mediated through the control of reelin and dab1 expression during brain ontogenesis.	en_US
dc.description.sponsorship	This work was supported by grants from Comisión Interministerial de Ciencia y Tecnología, Plan Nacional de Salud (SAF98–0060 to A.M. and SAF98–0106 to E.S.), by Marató de TV3 Foundation to E.S., by the National Cancer Institute (Grant CA41702) to Jonathan Cooper and B.H., and by the Japanese Ministry of Education, Science, and Culture to K.N. T.C. was supported in part by National Institutes of Health Cancer Center Support CORE Grant P30 CA21765 and by the American Lebanese Syrian Associated Charities. E.S., K.N., and T.C. were supported also by the Human Frontier Science Program Organization.	en_US
dc.format.extent	2168998 bytes	-
dc.format.mimetype	application/pdf	-
dc.language.iso	eng	en_US
dc.publisher	Society for Neuroscience	en_US
dc.rights	openAccess	en_US
dc.subject	Reelin	en_US
dc.subject	Dab1	en_US
dc.subject	Thyroid hormone	en_US
dc.subject	Neuronal migration	en_US
dc.subject	Cortical lamination	en_US
dc.subject	Brain development	en_US
dc.title	Thyroid hormone regulates reelin and dab1 expression during brain development	en_US
dc.type	artículo	en_US
dc.description.peerreviewed	Peer reviewed	en_US
dc.relation.publisherversion	http://www.jneurosci.org/cgi/content/short/19/16/6979	en_US
dc.type.coar	http://purl.org/coar/resource_type/c_6501	es_ES
item.fulltext	With Fulltext	-
item.languageiso639-1	en	-
item.openairecristype	http://purl.org/coar/resource_type/c_18cf	-
item.openairetype	artículo	-
item.cerifentitytype	Publications	-
item.grantfulltext	open	-
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