Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/24405
Share/Export:
logo share SHARE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

Thyroid hormone regulates reelin and dab1 expression during brain development

AuthorsÁlvarez-Dolado, Manuel CSIC ORCID; Bernal, Juan CSIC ORCID; Muñoz Terol, Alberto CSIC ORCID
KeywordsReelin
Dab1
Thyroid hormone
Neuronal migration
Cortical lamination
Brain development
Issue Date15-Aug-1999
PublisherSociety for Neuroscience
CitationJournal of Neuroscience 19(16): 6979-6993 (1999)
AbstractThe reelin and dab1 genes are necessary for appropriate neuronal migration and lamination during brain development. Since these processes are controlled by thyroid hormone, we studied the effect of thyroid hormone deprivation and administration on the expression of reelin and dab1. As shown by Northern analysis, in situ hybridization, and immunohistochemistry studies, hypothyroid rats expressed decreased levels of reelin RNA and protein during the perinatal period [embryonic day 18 (E18) and postnatal day 0 (P0)]. The effect was evident in Cajal-Retzius cells of cortex layer I, as well as in layers V/VI, hippocampus, and granular neurons of the cerebellum. At later ages, however, Reelin was more abundant in the cortex, hippocampus, cerebellum, and olfactory bulb of hypothyroid rats (P5), and no differences were detected at P15. Conversely, Dab1 levels were higher at P0, and lower at P5 in hypothyroid animals. In line with these results, reelin RNA and protein levels were higher in cultured hippocampal slices from P0 control rats compared to those from hypothyroid animals. Significantly, thyroid-dependent regulation of reelin and dab1 was confirmed in vivo and in vitro by hormone treatment of hypothyroid rats and organotypic cultures, respectively. In both cases, thyroid hormone led to an increase in reelin expression. Our data suggest that the effects of thyroid hormone on neuronal migration may be in part mediated through the control of reelin and dab1 expression during brain ontogenesis.
Description15 pages, 11 figures.-- et al.
Publisher version (URL)http://www.jneurosci.org/cgi/content/short/19/16/6979
URIhttp://hdl.handle.net/10261/24405
ISSN1529-2401
Appears in Collections:(IIBM) Artículos

Files in This Item:
File Description SizeFormat
Thyroid hormone regulates.pdf2,12 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

Page view(s)

338
checked on May 17, 2022

Download(s)

216
checked on May 17, 2022

Google ScholarTM

Check


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.