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Título

TNF-alpha and hyperandrogenism: a clinical, biochemical, and molecular genetic study

AutorEscobar-Morreale, Héctor F.; Calvo, Rosa M. ; Sancho, José; San Millán, José L.
Fecha de publicaciónago-2001
EditorEndocrine Society
CitaciónJournal of Clinical Endocrinology and Metabolism 86(8): 3761-3767 (2001)
ResumenTo evaluate the role of TNF-alpha in the pathogenesis of hyperandrogenism, we have evaluated the serum TNF-alpha levels, as well as several polymorphisms in the promoter region of the TNF-alpha gene, in a group of 60 hyperandrogenic patients and 27 healthy controls matched for body mass index. Hyperandrogenic patients presented with mildly increased serum TNF-alpha levels as compared with controls (mean[median] +/- SD: 7.2[7.0] +/- 3.3 pg/ml vs. 5.6[4.4] +/- 4.0 pg/ml, P < 0.02). Although no differences in body mass index and insulin resistance indexes were observed between patients and controls, when subjects were classified by body weight, serum TNF-alpha was increased only in lean patients as compared with lean controls, but this difference was not statistically significant when comparing obese patients with obese controls. The TNF-alpha gene polymorphisms studied here (-1196C/T, -1125G/C, -1031T/C, -863C/A, -857C/T, -316G/A, -308G/A, -238G/A, and -163G/A) were equally distributed in hyperandrogenic patients and controls. However, carriers of the -308A variant presented with increased basal and leuprolide-stimulated serum androgens and 17-hydroxyprogesterone levels when considering patients and controls as a group. No differences were observed in serum TNF-alpha levels, body mass index, and insulin resistance indexes, depending on the presence or absence of these variants. In conclusion, our present results suggest that the TNF-alpha system might contribute to the pathogenesis of hyperandrogenism, independent of obesity and insulin resistance. However, elucidation of the precise mechanisms underlying the relationship between the TNF-alpha system and androgen excess is needed before considering TNF-alpha as a significant contributing factor to the development of hyperandrogenism.
Descripción7 pages, 1 figure, 3 tables.-- This work was presented at the 82nd Annual Meeting of The Endocrine Society, Toronto, Canada, June 21–24, 2000.
Versión del editorhttp://jcem.endojournals.org/cgi/content/full/86/8/3761
URIhttp://hdl.handle.net/10261/24382
ISSN0021-972X
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