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Title

Keratinocyte growth factor induces angiogenesis and protects endothelial barrier function

AuthorsGillis, Paul; Savla, Ushma; Volpert, Olga V.; Jiménez, Benilde ; Waters, Christopher M.; Panos, Ralph J.; Bouck, Noël P.
KeywordsKGF
Angiogenesis
Vascular permeability
Issue DateJun-1999
PublisherCompany of Biologists
CitationJournal of Cell Science 112 (12): 2049-2057 (1999)
AbstractKeratinocyte growth factor (KGF), also called fibroblast growth factor-7, is widely known as a paracrine growth and differentiation factor that is produced by mesenchymal cells and has been thought to act specifically on epithelial cells. Here it is shown to affect a new cell type, the microvascular endothelial cell. At subnanomolar concentrations KGF induced in vivo neovascularization in the rat cornea. In vitro it was not effective against endothelial cells cultured from large vessels, but did act directly on those cultured from small vessels, inducing chemotaxis with an ED50 of 0.02-0.05 ng/ml, stimulating proliferation and activating mitogen activated protein kinase (MAPK). KGF also helped to maintain the barrier function of monolayers of capillary but not aortic endothelial cells, protecting against hydrogen peroxide and vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) induced increases in permeability with an ED50 of 0.2-0.5 ng/ml. These newfound abilities of KGF to induce angiogenesis and to stabilize endothelial barriers suggest that it functions in microvascular tissue as it does in epithelial tissues to protect them against mild insults and to speed their repair after major damage.
Description9 pages, 6 figures, 1 table.
Publisher version (URL)http://jcs.biologists.org/cgi/content/abstract/112/12/2049
URIhttp://hdl.handle.net/10261/24378
ISSN0021-9533
Appears in Collections:(IIBM) Artículos
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