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Título

The expression of the sodium/iodide symporter is up-regulated in the thyroid of fetuses of iodine-deficient rats

AutorSchröder-van der Elst, Janny P.; Heide, Daan van der; Obregón, María Jesús
Fecha de publicaciónsep-2001
EditorEndocrine Society
CitaciónEndocrinology 142(9): 3736-3741 (2001)
ResumenIs the fetal thyroid already capable to increase its iodide uptake in response to iodine deficiency? To answer this question, we analyzed the expression of the Na(+)/I(-) symporter and several other genes in the thyroid of rat fetuses at 21 d of gestation from control mothers presenting a mild or more severe iodine deficiency. Female rats were placed on a low iodine diet, not supplemented, or supplemented with iodide or perchlorate for 3 months. The maternal and fetal thyroidal iodide uptake was measured 24 h after injection of 10 microCi Na (125)I into the dams. The absolute iodide uptake of the maternal thyroid was unchanged in a low iodine diet, not supplemented, compared with one supplemented with iodide. In contrast, the fetal thyroid absolute iodide uptake of a low iodine diet, not supplemented, and one supplemented with perchlorate was decreased by 70% and 95% compared with that supplemented with iodide. Na(+)/I(-) symporter mRNA was detected in the fetal thyroid of supplemented with iodide and increased about 2- and 4- fold in the thyroid of fetuses from a low iodine diet, not supplemented, and one supplemented with perchlorate, respectively. Na(+)/I(-) symporter expression was induced in the fetal side of the placenta in both a low iodine diet, not supplemented, and one supplemented with perchlorate; in contrast, Na(+)/I(-) symporter mRNA was never detected in the maternal side of the placenta. Fetal thyroid thyroglobulin and type I deiodinase mRNA contents were only significantly increased with a diet supplemented with perchlorate. Glucose transporter 4 mRNA was decreased in the fetal thyroid of both a low iodine diet, not supplemented, and one supplemented with perchlorate compared with one supplemented with iodide. In conclusion, although the up-regulation of Na(+)/I(-) symporter expression in fetal thyroid and placenta in the low iodine diet, not supplemented group did not lead to restoration of a normal absolute iodide uptake, our data show that all adaptive and/or defending mechanisms against iodine deficiency are already present in the fetus.
Descripción6 pages, 6 figures.-- Part of the study was presented, in preliminary form, at the 25th Annual Meeting of the European Thyroid Association, Athens, Greece, May 31–June 3, 1998, and the American Thyroid Association, Colorado Springs, Colorado, September 16–19, 1998.-- et al.
Versión del editorhttp://endo.endojournals.org/cgi/content/full/142/9/3736
URIhttp://hdl.handle.net/10261/24373
ISSN0013-7227
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