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Título: | Cyclic AMP can decrease expression of genes subject to catabolite repression in Saccharomyces cerevisiae |
Autor: | Zaragoza, Óscar CSIC ORCID; Lindley, Chris; Gancedo, Juana M. | Fecha de publicación: | abr-1999 | Editor: | American Society for Microbiology | Citación: | Journal of Virology 181(8): 2640-2642 (1999) | Resumen: | External cyclic AMP (cAMP) hindered the derepression of gluconeogenic enzymes in a pde2 mutant ofSaccharomyces cerevisiae, but it did not prevent invertase derepression. cAMP reduced nearly 20-fold the transcription driven by upstream activation sequence (UAS1FBP1) from FBP1, encoding fructose-1,6-bisphosphatase; it decreased 2-fold the activation of transcription by UAS2FBP1. Nuclear extracts from cells derepressed in the presence of cAMP were impaired in the formation of specific UASFBP1-protein complexes in band shift experiments. cAMP does not appear to act through the repressing protein Mig1. Control of FBP1 transcription through cAMP is redundant with other regulatory mechanisms. | Descripción: | 3 pages, 2 figures, 2 table. | Versión del editor: | http://jb.asm.org/cgi/content/short/181/8/2640 | URI: | http://hdl.handle.net/10261/24347 | ISSN: | 1098-5530 |
Aparece en las colecciones: | (IIBM) Artículos |
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