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Cytokine production by TLR7lig-Pp3 and TLR7lig

AuthorsLosada Méndez, Jorge; Palomares, Francisca; Gómez, Francisca; Ramírez-López, Pedro; Ramos-Soriano, Javier; Torres, María José; Mayorga, Cristobalina; Rojo, Francisco Javier
KeywordsDendritic cells
Cell culture
Cytokines type 2 and type 1 immnune response
Issue Date2021
CitationJorge Losada Méndez, Francisca Palomares, Francisca Gómez, Pedro Ramírez-López, Javier Ramos-Soriano, María José Torres, Cristobalina Mayorga and Javier Rojo. Cytokine production by TLR7lig-Pp3 and TLR7lig. [Dataset]. 2021
AbstractProduction of cytokine into the culture supernatant from DCs. Our analysis in allergic patients compared to tolerant controls detected significant increases of IL-5 and IFN with all the conditions containing TLR7lig (TLR7lig, TLR7lig-Pp3 and TLR7lig plus Pp3 in separately way). we observed that TLR7lig-Pp3 induced significant lower IL-4 and IL-5 levels whilst higher IFNγ levels compared to the Pp3 only in allergic patients, indicating the specific immunomodulatory capacity of this compound.
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