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Chimeric protein with high antimicrobial activity

AuthorsMartínez Fernández, Beatriz CSIC ORCID ; García-Suárez, María del Mar; Rodríguez, Ana CSIC ORCID ; Rodríguez-Rubio, Lorena; Lavigne, Rob
Issue Date6-Jun-2019
CitationWO2019105936 A1
AbstractThe present invention relates to a chimeric protein comprising the CHAP catalytic domain of the endolysin LysRODI from phage PhiiPLA-RODI and the SH3b cell wall binding domain of the endolysin LysH5 from phage phiiPLA88. This chimeric protein shows an improved lytic activity again Staphylococcus sp. and a higher stability than the other endolysins of the state of the art. The invention also relates to a polynucleotide encoding the chimeric protein, and the host cell or the composition comprising the chimeric protein or the polynucleotide encoding thereof, as well as its use for the treatmentand!or preventionof an infection of Staphylococcus sp, and!or for removing, inhibiting and!or preventing Staphylococcus sp. biofilm formation on abiotic surfaces, or for removing and!or preventing the Staphylococcus sp. contamination offoods and!or abiotic surfaces
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