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Título

Predictive value of nuclear factor κB activity and plasma cytokine levels in patients with sepsis

AutorArnalich, Francisco; García-Palomero, Esther; Renart, Jaime ; Montiel, Carmen
Fecha de publicaciónabr-2000
EditorAmerican Society for Microbiology
CitaciónInfection and Immunity 68(4): 1942-1945 (2000)
ResumenThe relationship between fluctuating cytokine concentrations in plasma and the outcome of sepsis is complex. We postulated that early measurement of the activation of nuclear factor kappaB (NF-kappaB), a transcriptional regulatory protein involved in proinflammatory cytokine expression, may help to predict the outcome of sepsis. We determined NF-kappaB activation in peripheral blood mononuclear cells of 34 patients with severe sepsis (23 survivors and 11 nonsurvivors) and serial concentrations of inflammatory cytokines (interleukin-6, interleukin-1, and tumor necrosis factor) and various endogenous antagonists in plasma. NF-kappaB activity was significantly higher in nonsurvivors and correlated strongly with the severity of illness (APACHE II score), although neither was related to the cytokine levels. Apart from NF-kappaB activity, the interleukin-1 receptor antagonist was the only cytokine tested whose level in plasma was of value in predicting mortality by logistic regression analysis. These results underscore the prognostic value of early measurement of NF-kappaB activity in patients with severe sepsis.
Descripción4 pages, 2 figures, 2 tables.-- et al.
Versión del editorhttp://dx.doi.org/10.1128/IAI.68.4.1942-1945.2000
URIhttp://hdl.handle.net/10261/24262
DOI10.1128/IAI.68.4.1942-1945.2000
ISSN0019-9567
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