Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/24253
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dc.contributor.authorMedina, Diego L.-
dc.contributor.authorSantisteban, Pilar-
dc.date.accessioned2010-05-13T08:43:25Z-
dc.date.available2010-05-13T08:43:25Z-
dc.date.issued2000-08-
dc.identifier.citationEuropean Journal of Endocrinology 143(2): 161-178 (2000)en_US
dc.identifier.issn0804-4643-
dc.identifier.urihttp://hdl.handle.net/10261/24253-
dc.description18 pages, 2 figures, 1 table.-- Review.en_US
dc.description.abstractThis review is focused on the most recent knowledge on growth control of rat thyroid cell lines. We analyzed the effect of mitogenic as well as inhibitory agents, but mainly the proliferative effect elicited by thyrotropin (TSH). The classic cAMP-dependent protein kinase (PKA) signal transduction pathway involved in TSH-mediated cell growth is analyzed exhaustively. We have also reviewed new concepts about the participation of other effectors such as small GTPases and phosphatidyl inositol-3-kinase (PI3-K) and the new data about the existence of a cAMP-dependent but PKA-independent pathway. Finally, we give information about TSH induction of cell cycle-related genes, such as G1 cyclins, cyclin-dependent kinases (CDKs) and CDK inhibitors.en_US
dc.description.sponsorshipWe are grateful to Dirección General de Investigación Científica y Tecnológica (Grant PM97±0065), Comunidad Autónoma de Madrid (Grants 08.1/0025.1/97 and 1/99) and Fundación Salud 2000 (Spain) for supporting our work. DLM has a Fellowship from the Ministerio de Educación y Cultura (Spain)en_US
dc.format.extent326614 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherEuropean Society of Endocrinologyen_US
dc.rightsopenAccessen_US
dc.titleThyrotropin-dependent proliferation of in vitro rat thyroid cell systemsen_US
dc.typeartículoen_US
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://eje-online.org/cgi/reprint/143/2/161en_US
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
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