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Título

Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems

AutorMedina, Diego L.; Santisteban, Pilar
Fecha de publicaciónago-2000
EditorEuropean Society of Endocrinology
CitaciónEuropean Journal of Endocrinology 143(2): 161-178 (2000)
ResumenThis review is focused on the most recent knowledge on growth control of rat thyroid cell lines. We analyzed the effect of mitogenic as well as inhibitory agents, but mainly the proliferative effect elicited by thyrotropin (TSH). The classic cAMP-dependent protein kinase (PKA) signal transduction pathway involved in TSH-mediated cell growth is analyzed exhaustively. We have also reviewed new concepts about the participation of other effectors such as small GTPases and phosphatidyl inositol-3-kinase (PI3-K) and the new data about the existence of a cAMP-dependent but PKA-independent pathway. Finally, we give information about TSH induction of cell cycle-related genes, such as G1 cyclins, cyclin-dependent kinases (CDKs) and CDK inhibitors.
Descripción18 pages, 2 figures, 1 table.-- Review.
Versión del editorhttp://eje-online.org/cgi/reprint/143/2/161
URIhttp://hdl.handle.net/10261/24253
ISSN0804-4643
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