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Title: | Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems |
Authors: | Medina, Diego L.; Santisteban, Pilar CSIC ORCID | Issue Date: | Aug-2000 | Publisher: | European Society of Endocrinology | Citation: | European Journal of Endocrinology 143(2): 161-178 (2000) | Abstract: | This review is focused on the most recent knowledge on growth control of rat thyroid cell lines. We analyzed the effect of mitogenic as well as inhibitory agents, but mainly the proliferative effect elicited by thyrotropin (TSH). The classic cAMP-dependent protein kinase (PKA) signal transduction pathway involved in TSH-mediated cell growth is analyzed exhaustively. We have also reviewed new concepts about the participation of other effectors such as small GTPases and phosphatidyl inositol-3-kinase (PI3-K) and the new data about the existence of a cAMP-dependent but PKA-independent pathway. Finally, we give information about TSH induction of cell cycle-related genes, such as G1 cyclins, cyclin-dependent kinases (CDKs) and CDK inhibitors. | Description: | 18 pages, 2 figures, 1 table.-- Review. | Publisher version (URL): | http://eje-online.org/cgi/reprint/143/2/161 | URI: | http://hdl.handle.net/10261/24253 | ISSN: | 0804-4643 |
Appears in Collections: | (IIBM) Artículos |
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