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Title

Lipophilic hydroxytyrosyl esters. Antioxidant activity in lipid matrices and biological systems

AuthorsTrujillo Pérez-Lanzac, Mariana; Mateos, Raquel CSIC ORCID ; Collantes de Teran, Laura; Espartero, José L.; Cert, María Rosa CSIC ORCID ; Jover, Maria; Alcudia-González, Felipe; Bautista Lorite, Juan; Cert, Arturo CSIC; Parrado, Juan
Issue Date2006
PublisherAmerican Chemical Society
CitationJournal of Agricultural and Food Chemistry 54(11): 3779-3785 (2006)
AbstractAntioxidant activities of lipophilic hydroxytyrosyl acetate, palmitate, oleate, and linoleate were compared with those of hydroxytyrosol, α-tocopherol, and butylhydroxytoluene (BHT) in both glyceridic matrix and biological systems. Aliquots of a glyceridic matrix spiked with various concentrations of antioxidant were subjected to accelerated oxidation in a Rancimat apparatus operated at 90 °C. The relationships between induction time (IT) and antioxidant concentration (mmol/kg) presented by hydroxytyrosol and hydroxytyrosyl acetate, palmitate, oleate, and linoleate were similar. Hydroxytyrosol and its esters showed greater antioxidant activity than α-tocopherol or BHT. We also evaluated the capacity of hydroxytyrosyl esters to protect proteins and lipids against oxidation caused by peroxyl radicals, using a brain homogenate as an ex vivo model. All tested compounds showed a protective effect in these systems, which was greater in preventing the generation of carbonyl groups in protein than of malondialdehyde in lipid. Inclusion of a lipophilic chain in the hydroxytyrosol molecule enhanced its antioxidant capacities in this biological model.
Publisher version (URL)https://doi.org/10.1021/jf060520z
URIhttp://hdl.handle.net/10261/242464
DOI10.1021/jf060520z
ISSN0021-8561
Appears in Collections:(IG) Artículos

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