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Título

Amphioxus functional genomics and the origins of vertebrate gene regulation

AutorMarlétaz, Ferdinand; Firbas, Panos; Maeso, Ignacio CSIC ORCID; Tena, Juan J. CSIC ORCID; Bogdanovic, Ozren CSIC ORCID; Perry, M.; Wyatt, Christopher D. R.; Calle-Mustienes, Elisa de la CSIC ORCID; Bertrand, Stephanie; Burguera, Demian; Acemel, Rafael D. CSIC ORCID; Van Heeringen, Simon J.; Naranjo, Silvia CSIC ORCID; Herrera-Úbeda, Carlos; Skvortsova, Ksenia; Jiménez-Gancedo, Sandra CSIC; Aldea, Daniel; Marquez, Yamile; Buono, Lorena CSIC ORCID; Kozmikova, Iryna; Permanyer, Jon; Louis, Alexandra; Albuixech-Crespo, Beatriz; Petillon, Yann Le; Leon, Anthony; Subirana, Lucie; Balwierz, Piotr J.; Duckett, Paul Edward; Farahani, Ensieh; Aury, Jean‐Marc; Mangenot, Sophie; Wincker, Patrick; Albalat, Ricard; Benito-Gutiérrez, Èlia; Cañestro, Cristian; Castro, Filipe; D’Aniello, Salvatore; Ferrier, David E. K.; Huang, Shengfeng; Laudet, Vincent; Marais, Gabriel A.B.; Pontarotti, Pierre; Schubert, Michael; Seitz, Hervé; Somorjai, Ildiko; Takahashi, Tokiharu; Mirabeau, Olivier; Xu, Anlong; Yu, Jr-Kai; Carninci, Piero; Martínez-Morales, Juan Ramón CSIC ORCID; Roest Crollius, Hugues; Kozmik, Zbynek; Weirauch, Matthew T.; Garcia-Fernàndez, Jordi; Lister, Ryan; Lenhard, Boris; Holland, Peter W. H.; Escrivá, Héctor CSIC ORCID; Gómez-Skarmeta, José Luis CSIC ORCID ; Irimia, Manuel
Palabras claveAmphioxus
Ancestral expression
Whole-genome duplications
Phylotypic period
Branchiostoma lanceolatum
Fecha de publicación6-dic-2018
EditorSpringer Nature
CitaciónNature 564: 64-70 (2018)
ResumenVertebrates have greatly elaborated the basic chordate body plan and evolved highly distinctive genomes that have been sculpted by two whole-genome duplications. Here we sequence the genome of the Mediterranean amphioxus (Branchiostoma lanceolatum) and characterize DNA methylation, chromatin accessibility, histone modifications and transcriptomes across multiple developmental stages and adult tissues to investigate the evolution of the regulation of the chordate genome. Comparisons with vertebrates identify an intermediate stage in the evolution of differentially methylated enhancers, and a high conservation of gene expression and its cis-regulatory logic between amphioxus and vertebrates that occurs maximally at an earlier mid-embryonic phylotypic period. We analyse regulatory evolution after whole-genome duplications, and find that—in vertebrates—over 80% of broadly expressed gene families with multiple paralogues derived from whole-genome duplications have members that restricted their ancestral expression, and underwent specialization rather than subfunctionalization. Counter-intuitively, paralogues that restricted their expression increased the complexity of their regulatory landscapes. These data pave the way for a better understanding of the regulatory principles that underlie key vertebrate innovations.
Versión del editorhttp://dx.doi.org/10.1038/s41586-018-0734-6
URIhttp://hdl.handle.net/10261/242299
DOI10.1038/s41586-018-0734-6
ISSN0028-0836
E-ISSN1476-4687
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