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Title

The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

AuthorsAndrés Juan, Celia; Pérez de Lastra, José Manuel ; Plou Gasca, Francisco José ; Pérez-Lebeña, Euardo
KeywordsROS
Oxidative stress
Macromolecules
Issue Date28-Apr-2021
PublisherMultidisciplinary Digital Publishing Institute
CitationInternational Journal of Molecular Sciences 22(9), 4642: 1-21 (2021)
AbstractLiving species are continuously subjected to all extrinsic forms of reactive oxidants and others that are produced endogenously. There is extensive literature on the generation and effects of reactive oxygen species (ROS) in biological processes, both in terms of alteration and their role in cellular signaling and regulatory pathways. Cells produce ROS as a controlled physiological process, but increasing ROS becomes pathological and leads to oxidative stress and disease. The induction of oxidative stress is an imbalance between the production of radical species and the antioxidant defense systems, which can cause damage to cellular biomolecules, including lipids, proteins and DNA. Cellular and biochemical experiments have been complemented in various ways to explain the biological chemistry of ROS oxidants. However, it is often unclear how this translates into chemical reactions involving redox changes. This review addresses this question and includes a robust mechanistic explanation of the chemical reactions of ROS and oxidative stress.
Publisher version (URL)https://doi.org/10.3390/ijms22094642
URIhttp://hdl.handle.net/10261/241982
DOI10.3390/ijms22094642
ISSN1661-6596
E-ISSN1422-0067
Appears in Collections:(ICP) Artículos
(IPNA) Artículos
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