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Título

Synthetic flavonoids cross the placenta in the rat and are found in fetal brain

AutorSchröder-van der Elst, Janny P.; Heide, Daan van der; Morreale de Escobar, Gabriella
Palabras claveThyroid hormones
Goitrogen
Fecha de publicaciónfeb-1998
EditorAmerican Physiological Society
CitaciónAmerican Journal of Physiology - Endocrinology and Metabolism 274: E253-E256 (1998)
ResumenThe synthetic flavonoid EMD-49209 is a potent inhibitor of the in vivo and in vitro binding of thyroxine (T4) to transthyretin (TTR). We studied the distribution of 125I-labeled EMD-49209 in maternal tissues, intestinal contents, and fetal tissues in rats that were 20 days pregnant (from 1 to 24 h after intravenous injection). The percent dose of EMD decreased quickly with time. In maternal brain no radioactive flavonoid could be detected. EMD was excreted very rapidly from the intestines. In the fetal compartment the percent dose of EMD increased with time; after 24 h it contained 17% of the EMD. The flavonoid was found in all fetal tissues investigated and also in the fetal brain. Because TTR concentrations are high in the fetal rat, especially in the brain, the transfer of flavonoid to the fetal brain might be linked to TTR expression. The presence of flavonoid in the fetal brain raises the possibility of an essential interference of flavonoids with the availability of T4 in the fetal compartment.
Descripción5 pages, 1 figure, 1 table.-- Part of this work was presented at the XIth meeting of the International Thyroid Congress, Toronto, Canada, September 10–15, 1995.-- et al.
Versión del editorhttp://ajpendo.physiology.org/cgi/content/full/274/2/E253
URIhttp://hdl.handle.net/10261/24178
ISSN0193-1849
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